| pubmed-article:11313480 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11313480 | lifeskim:mentions | umls-concept:C1334291 | lld:lifeskim |
| pubmed-article:11313480 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:11313480 | lifeskim:mentions | umls-concept:C2323499 | lld:lifeskim |
| pubmed-article:11313480 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:11313480 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:11313480 | lifeskim:mentions | umls-concept:C1150423 | lld:lifeskim |
| pubmed-article:11313480 | lifeskim:mentions | umls-concept:C1426208 | lld:lifeskim |
| pubmed-article:11313480 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
| pubmed-article:11313480 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:11313480 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11313480 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:11313480 | pubmed:dateCreated | 2001-4-23 | lld:pubmed |
| pubmed-article:11313480 | pubmed:abstractText | TEL-JAK2 fusion proteins, which are a result of t(9;12)(p24;p13) translocations associated with human leukemia, activate Stat5 in vitro and in vivo and cause a myelo- and lymphoproliferative disease in a murine bone marrow transplant model. We report that Socs-1, a member of the SOCS family of endogenous inhibitors of JAKs and STATs, inhibits transformation of Ba/F3 cells by TEL-JAK2 but has no effect on Ba/F3 cells transformed by BCR-ABL, TEL-ABL, or TEL-platelet-derived growth factor receptor beta. TEL-JAK2, in addition to activating Stat5, associates with Shc and Grb2 and induces activation of Erk2, and expression of Socs-1 inhibits engagement of each of these signaling molecules. TEL-JAK2 kinase activity is inhibited by Socs-1, as assessed by in vitro kinase assays. In addition, Socs-1 induces proteasomal degradation of TEL-JAK2. Mutational analysis indicates that the SOCS box of Socs-1 is required for proteasomal degradation and for abrogation of growth of TEL-JAK2-transformed cells. Furthermore, murine bone marrow transplant assays demonstrate that expression of Socs-1 prolongs latency of TEL-JAK2-mediated disease in vivo. Collectively, these data indicate that Socs-1 inhibits TEL-JAK2 in vitro and in vivo through inhibition of kinase activity and induction of TEL-JAK2 protein degradation. | lld:pubmed |
| pubmed-article:11313480 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11313480 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11313480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313480 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11313480 | pubmed:month | May | lld:pubmed |
| pubmed-article:11313480 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:11313480 | pubmed:author | pubmed-author:GillilandD... | lld:pubmed |
| pubmed-article:11313480 | pubmed:author | pubmed-author:KutokJJ | lld:pubmed |
| pubmed-article:11313480 | pubmed:author | pubmed-author:SternbergD... | lld:pubmed |
| pubmed-article:11313480 | pubmed:author | pubmed-author:SchwallerJJ | lld:pubmed |
| pubmed-article:11313480 | pubmed:author | pubmed-author:FrantsveJJ | lld:pubmed |
| pubmed-article:11313480 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11313480 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:11313480 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11313480 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11313480 | pubmed:pagination | 3547-57 | lld:pubmed |
