| pubmed-article:11301023 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C0162508 | lld:lifeskim |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C0010749 | lld:lifeskim |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C1337096 | lld:lifeskim |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11301023 | lifeskim:mentions | umls-concept:C0445450 | lld:lifeskim |
| pubmed-article:11301023 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11301023 | pubmed:dateCreated | 2001-4-13 | lld:pubmed |
| pubmed-article:11301023 | pubmed:abstractText | Sympathetic neurons require nerve growth factor for survival and die by apoptosis in its absence. Key steps in the death pathway include c-Jun activation, mitochondrial cytochrome c release, and caspase activation. Here, we show that neurons rescued from NGF withdrawal-induced apoptosis by expression of dominant-negative c-Jun do not release cytochrome c from their mitochondria. Furthermore, we find that the mRNA for BIM(EL), a proapoptotic BCL-2 family member, increases in level after NGF withdrawal and that this is reduced by dominant-negative c-Jun. Finally, overexpression of BIM(EL) in neurons induces cytochrome c redistribution and apoptosis in the presence of NGF, and neurons injected with Bim antisense oligonucleotides or isolated from Bim(-/-) knockout mice die more slowly after NGF withdrawal. | lld:pubmed |
| pubmed-article:11301023 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11301023 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11301023 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11301023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11301023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11301023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11301023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11301023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11301023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11301023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11301023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11301023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11301023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11301023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11301023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11301023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11301023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11301023 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11301023 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11301023 | pubmed:issn | 0896-6273 | lld:pubmed |
| pubmed-article:11301023 | pubmed:author | pubmed-author:BernardOO | lld:pubmed |
| pubmed-article:11301023 | pubmed:author | pubmed-author:AxH AHA | lld:pubmed |
| pubmed-article:11301023 | pubmed:author | pubmed-author:WhitfieldJJ | lld:pubmed |
| pubmed-article:11301023 | pubmed:author | pubmed-author:NeameS JSJ | lld:pubmed |
| pubmed-article:11301023 | pubmed:author | pubmed-author:PaquetLL | lld:pubmed |
| pubmed-article:11301023 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11301023 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:11301023 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11301023 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11301023 | pubmed:pagination | 629-43 | lld:pubmed |
| pubmed-article:11301023 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:11301023 | pubmed:meshHeading | pubmed-meshheading:11301023... | lld:pubmed |
| pubmed-article:11301023 | pubmed:meshHeading | pubmed-meshheading:11301023... | lld:pubmed |
| pubmed-article:11301023 | pubmed:meshHeading | pubmed-meshheading:11301023... | lld:pubmed |
| pubmed-article:11301023 | pubmed:meshHeading | pubmed-meshheading:11301023... | lld:pubmed |
| pubmed-article:11301023 | pubmed:meshHeading | pubmed-meshheading:11301023... | lld:pubmed |
| pubmed-article:11301023 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11301023 | pubmed:articleTitle | Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. | lld:pubmed |
| pubmed-article:11301023 | pubmed:affiliation | Eisai London Research Laboratories, Bernard Katz Building, University College London, Gower Street, WC1E 6BT, London, United Kingdom. | lld:pubmed |
| pubmed-article:11301023 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11301023 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:24516 | entrezgene:pubmed | pubmed-article:11301023 | lld:entrezgene |
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