| pubmed-article:11298133 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11298133 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:11298133 | lifeskim:mentions | umls-concept:C0524910 | lld:lifeskim |
| pubmed-article:11298133 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:11298133 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11298133 | pubmed:dateCreated | 2001-4-12 | lld:pubmed |
| pubmed-article:11298133 | pubmed:abstractText | A T helper (Th)1 to Th2 shift has been proposed to be a critical pathogenic determinant in chronic hepatitis C. Here, we evaluated mitogen-induced and hepatitis C virus (HCV) core antigen-induced cytokine production in 28 patients with biopsy-proven chronic hepatitis C. Flow cytometry demonstrated that after mitogenic stimulation the percentage of Th2 cells (IL-4 + or IL-13 +) and Th0 cells (IFN-gamma/IL-4 + or IL-2/IL-13 +) did not differ between patients and controls. In contrast, the percentage of Th1 cells (IFN-gamma + or IL-2 +) was significantly increased in CD4 +, CD8 +, 'naive'-CD45RA + and 'memory'-CD45RO + T-cell subsets from patients versus controls. Similar results were obtained by ELISA testing supernatants from mitogen-stimulated, unfractionated peripheral blood mononuclear cell (PBMC) cultures. Interferon-alpha treatment was associated with a reduction in the mitogen-induced Th1 cytokine response in those patients who cleared their plasma HCV-RNA. Analysis of cytokine expression by CD4 + T cells after HCV core antigen stimulation in a subgroup of 13 chronic hepatitis C patients demonstrated no cytokine response in 74% of these patients and an IFN-gamma-restricted response in 26%. Finally, no Th2 shift was found in lipopolysaccharide-stimulated monocytes. These data indicate that a Th1 to Th2 shift does not occur in chronic hepatitis C. | lld:pubmed |
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| pubmed-article:11298133 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11298133 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11298133 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11298133 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11298133 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11298133 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11298133 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11298133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11298133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11298133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11298133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11298133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11298133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11298133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11298133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11298133 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11298133 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11298133 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:11298133 | pubmed:author | pubmed-author:RocchiGG | lld:pubmed |
| pubmed-article:11298133 | pubmed:author | pubmed-author:CerasaroMM | lld:pubmed |
| pubmed-article:11298133 | pubmed:author | pubmed-author:LupoGG | lld:pubmed |
| pubmed-article:11298133 | pubmed:author | pubmed-author:BongiovanniBB | lld:pubmed |
| pubmed-article:11298133 | pubmed:author | pubmed-author:AngelicoMM | lld:pubmed |
| pubmed-article:11298133 | pubmed:author | pubmed-author:CarvelliCC | lld:pubmed |
| pubmed-article:11298133 | pubmed:author | pubmed-author:UccelliAA | lld:pubmed |
| pubmed-article:11298133 | pubmed:author | pubmed-author:BergaminiAA | lld:pubmed |
| pubmed-article:11298133 | pubmed:author | pubmed-author:CapozziMM | lld:pubmed |
| pubmed-article:11298133 | pubmed:author | pubmed-author:DemirBB | lld:pubmed |
| pubmed-article:11298133 | pubmed:author | pubmed-author:BolacchiFF | lld:pubmed |
| pubmed-article:11298133 | pubmed:author | pubmed-author:FaggioliEE | lld:pubmed |
| pubmed-article:11298133 | pubmed:author | pubmed-author:CepparuloMM | lld:pubmed |
| pubmed-article:11298133 | pubmed:author | pubmed-author:NiuttaPP | lld:pubmed |
| pubmed-article:11298133 | pubmed:author | pubmed-author:PiscitelliEE | lld:pubmed |
| pubmed-article:11298133 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11298133 | pubmed:volume | 123 | lld:pubmed |
| pubmed-article:11298133 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11298133 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11298133 | pubmed:pagination | 451-8 | lld:pubmed |
| pubmed-article:11298133 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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