| pubmed-article:11267640 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11267640 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:11267640 | lifeskim:mentions | umls-concept:C0221198 | lld:lifeskim |
| pubmed-article:11267640 | lifeskim:mentions | umls-concept:C0454606 | lld:lifeskim |
| pubmed-article:11267640 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:11267640 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11267640 | pubmed:dateCreated | 2001-3-27 | lld:pubmed |
| pubmed-article:11267640 | pubmed:abstractText | Peripheral administration of the 5-hydroxytryptamine (5-HT)(2C/1B) agonist 1-(m-chlorophenyl)piperazine (m-CPP) produces abnormal orofacial movements in rats. We have previously shown that this behavior is mediated by 5-HT(2C) receptors in the subthalamic nucleus [Neuroscience 72 (1996) 117]. The present studies examined this effect after serotonin depletion to determine whether removal of endogenous serotonin affected this behavioral response and/or subthalamic 5-HT(2C) receptors. Rats received an intraventricular infusion of the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT, 100 mg/10 ml) or vehicle after desipramine pretreatment (25 mg/kg ip). The efficacy of serotonin depletion was confirmed by a decrease in serotonin uptake sites measured by autoradiography. Oral dyskinesia induced by peripheral administration of m-CPP (1.0 mg/kg ip) was markedly increased in lesioned rats compared to sham-operated controls 4 and 8 but not 12 days after the lesion. A subset of lesioned rats that displayed transient seizures after m-CPP injection did not prevent the measurement of oral dyskinesia during the observation period. No differences in 5-HT(2C) receptor levels were found with ligand-binding autoradiography in the subthalamic nucleus, or in other brain regions that express this receptor, in rats sacrificed 5 days following 5,7-DHT lesions. The data indicate that lesion of serotonergic neurons in adult rats induces a transient increase in motor responses mediated by subthalamic 5-HT(2C) receptors. These data suggest that functional alterations in serotonergic transmission in the subthalamic nucleus may be involved in the pathophysiology of hyperkinetic movement disorders. | lld:pubmed |
| pubmed-article:11267640 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11267640 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11267640 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11267640 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11267640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11267640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11267640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11267640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11267640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11267640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11267640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11267640 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11267640 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11267640 | pubmed:issn | 0091-3057 | lld:pubmed |
| pubmed-article:11267640 | pubmed:author | pubmed-author:MehtaAA | lld:pubmed |
| pubmed-article:11267640 | pubmed:author | pubmed-author:ChesseletM... | lld:pubmed |
| pubmed-article:11267640 | pubmed:author | pubmed-author:Eberle-WangKK | lld:pubmed |
| pubmed-article:11267640 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11267640 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:11267640 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11267640 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11267640 | pubmed:pagination | 347-53 | lld:pubmed |
| pubmed-article:11267640 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:11267640 | pubmed:meshHeading | pubmed-meshheading:11267640... | lld:pubmed |
| pubmed-article:11267640 | pubmed:meshHeading | pubmed-meshheading:11267640... | lld:pubmed |
| pubmed-article:11267640 | pubmed:meshHeading | pubmed-meshheading:11267640... | lld:pubmed |
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| pubmed-article:11267640 | pubmed:meshHeading | pubmed-meshheading:11267640... | lld:pubmed |
| pubmed-article:11267640 | pubmed:meshHeading | pubmed-meshheading:11267640... | lld:pubmed |
| pubmed-article:11267640 | pubmed:meshHeading | pubmed-meshheading:11267640... | lld:pubmed |
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| pubmed-article:11267640 | pubmed:meshHeading | pubmed-meshheading:11267640... | lld:pubmed |
| pubmed-article:11267640 | pubmed:meshHeading | pubmed-meshheading:11267640... | lld:pubmed |
| pubmed-article:11267640 | pubmed:meshHeading | pubmed-meshheading:11267640... | lld:pubmed |
| pubmed-article:11267640 | pubmed:meshHeading | pubmed-meshheading:11267640... | lld:pubmed |
| pubmed-article:11267640 | pubmed:meshHeading | pubmed-meshheading:11267640... | lld:pubmed |
| pubmed-article:11267640 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11267640 | pubmed:articleTitle | Increased m-CPP-induced oral dyskinesia after lesion of serotonergic neurons. | lld:pubmed |
| pubmed-article:11267640 | pubmed:affiliation | Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA. | lld:pubmed |
| pubmed-article:11267640 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11267640 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
