| pubmed-article:11257421 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11257421 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:11257421 | lifeskim:mentions | umls-concept:C0140057 | lld:lifeskim |
| pubmed-article:11257421 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:11257421 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11257421 | pubmed:dateCreated | 2001-3-21 | lld:pubmed |
| pubmed-article:11257421 | pubmed:abstractText | P-glycoprotein (P-gp) and organic anion transporting polypeptides (Oatp) are expressed at the blood-brain barrier (BBB). There is little functional evidence for Oatp-mediated transport at the BBB. The peptidic delta opioid-receptor agonist [D-penicillamine(2,5)]-enkephalin (DPDPE) is a substrate of mdr1a P-gp and Oatp2. The present study evaluated the influence of these transporters on brain uptake of DPDPE by in situ perfusion in mice. Brain uptake was increased approximately 12-fold in mice lacking P-gp in the BBB, but the P-gp inhibitor dexverapamil did not increase uptake in P-gp-competent mice. In P-gp-deficient mice, DPDPE uptake was saturable (K(m) approximately 24 mM), and was inhibited by dexverapamil and the Oatp2 substrates digoxin, estradiol-17beta-glucuronide and fexofenadine. These results confirm P-gp-mediated efflux of DPDPE, and suggest functional uptake transport of DPDPE by Oatp, at the murine BBB. | lld:pubmed |
| pubmed-article:11257421 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11257421 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11257421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11257421 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11257421 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11257421 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:11257421 | pubmed:author | pubmed-author:DucharmeJJ | lld:pubmed |
| pubmed-article:11257421 | pubmed:author | pubmed-author:PollackG MGM | lld:pubmed |
| pubmed-article:11257421 | pubmed:author | pubmed-author:DagenaisCC | lld:pubmed |
| pubmed-article:11257421 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11257421 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:11257421 | pubmed:volume | 301 | lld:pubmed |
| pubmed-article:11257421 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11257421 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11257421 | pubmed:pagination | 155-8 | lld:pubmed |
| pubmed-article:11257421 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
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| pubmed-article:11257421 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11257421 | pubmed:articleTitle | Uptake and efflux of the peptidic delta-opioid receptor agonist. | lld:pubmed |
| pubmed-article:11257421 | pubmed:affiliation | Division of Drug Delivery and Disposition, School of Pharmacy, Beard Hall CB 7360, The University of North Carolina at Chapel Hill, NC 27599-7360, USA. | lld:pubmed |
| pubmed-article:11257421 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11257421 | lld:pubmed |
