pubmed-article:11249710 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11249710 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
pubmed-article:11249710 | lifeskim:mentions | umls-concept:C0035685 | lld:lifeskim |
pubmed-article:11249710 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
pubmed-article:11249710 | lifeskim:mentions | umls-concept:C0725066 | lld:lifeskim |
pubmed-article:11249710 | lifeskim:mentions | umls-concept:C0332185 | lld:lifeskim |
pubmed-article:11249710 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:11249710 | pubmed:dateCreated | 2001-3-15 | lld:pubmed |
pubmed-article:11249710 | pubmed:abstractText | An RNA-dependent RNA polymerase denoted nonstructural protein 5B (NS5B) is the central enzyme in replication of the hepatitis C virus genome. Recent advances in the biochemical and structural understanding of NS5B include solubilization and purification of the full-length enzyme and various truncated forms. In vitro conditions for NS5B-catalyzed primer elongation using both homo- and heteropolymeric RNA templates were discovered. The crystal structure of the NS5B apoenzyme revealed a globular shape unique among polymerases, and implicated new structural features important for binding the RNA template and cognate ribonucleotide substrates. The crystallographic results also provided a structure-based framework for biochemical analyses and drug-design efforts. Finally, inhibitors of HCV RNA-dependent RNA polymerase have been reported. | lld:pubmed |
pubmed-article:11249710 | pubmed:language | eng | lld:pubmed |
pubmed-article:11249710 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11249710 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:11249710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11249710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11249710 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11249710 | pubmed:month | Nov | lld:pubmed |
pubmed-article:11249710 | pubmed:issn | 1472-4472 | lld:pubmed |
pubmed-article:11249710 | pubmed:author | pubmed-author:WeberP CPC | lld:pubmed |
pubmed-article:11249710 | pubmed:author | pubmed-author:LesburgC ACA | lld:pubmed |
pubmed-article:11249710 | pubmed:author | pubmed-author:RadfarRR | lld:pubmed |
pubmed-article:11249710 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11249710 | pubmed:volume | 1 | lld:pubmed |
pubmed-article:11249710 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11249710 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11249710 | pubmed:pagination | 289-96 | lld:pubmed |
pubmed-article:11249710 | pubmed:dateRevised | 2005-11-16 | lld:pubmed |
pubmed-article:11249710 | pubmed:meshHeading | pubmed-meshheading:11249710... | lld:pubmed |
pubmed-article:11249710 | pubmed:meshHeading | pubmed-meshheading:11249710... | lld:pubmed |
pubmed-article:11249710 | pubmed:meshHeading | pubmed-meshheading:11249710... | lld:pubmed |
pubmed-article:11249710 | pubmed:meshHeading | pubmed-meshheading:11249710... | lld:pubmed |
pubmed-article:11249710 | pubmed:meshHeading | pubmed-meshheading:11249710... | lld:pubmed |
pubmed-article:11249710 | pubmed:meshHeading | pubmed-meshheading:11249710... | lld:pubmed |
pubmed-article:11249710 | pubmed:year | 2000 | lld:pubmed |
pubmed-article:11249710 | pubmed:articleTitle | Recent advances in the analysis of HCV NS5B RNA-dependent RNA polymerase. | lld:pubmed |
pubmed-article:11249710 | pubmed:affiliation | Department of Structural Chemistry, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. Charles.Lesburg@spcorp.com | lld:pubmed |
pubmed-article:11249710 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:11249710 | pubmed:publicationType | Review | lld:pubmed |