| pubmed-article:11246230 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11246230 | lifeskim:mentions | umls-concept:C0019425 | lld:lifeskim |
| pubmed-article:11246230 | lifeskim:mentions | umls-concept:C0004112 | lld:lifeskim |
| pubmed-article:11246230 | lifeskim:mentions | umls-concept:C0027831 | lld:lifeskim |
| pubmed-article:11246230 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:11246230 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:11246230 | lifeskim:mentions | umls-concept:C0308269 | lld:lifeskim |
| pubmed-article:11246230 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11246230 | pubmed:dateCreated | 2001-3-14 | lld:pubmed |
| pubmed-article:11246230 | pubmed:abstractText | Individuals with neurofibromatosis 1 (NF1) develop low-grade astrocytomas at an increased frequency. To gain insight into the function of the Nf1 gene product as a growth regulator for astrocytes, we examined mice heterozygous for a targeted Nf1 mutation. In our previous studies, we demonstrated increased numbers of proliferating astrocytes in Nf1 heterozygote (Nf1+/-) mice in vivo. We now show that cultured Nf1+/- astrocytes exhibit a cell-autonomous growth advantage in vitro associated with increased p21-ras pathway activation. Furthermore, we demonstrate that Nf1+/-;wild-type N-ras mice have a similar astrocyte growth advantage in vitro and in vivo as either oncogenic N-ras or Nf1+/-; oncogenic N-ras mice. Lastly, mice heterozygous for targeted defects in both Nf1 and p53 as well as Nf1 and Rb exhibit 3- and 2.5-fold increases in astrocyte proliferation in vivo, respectively, suggesting that abnormalities in Nf1- and p53/Rb-regulated pathways cooperate in the heterozygous state to confer a growth advantage for brain astrocytes. Collectively, these results provide evidence for a cell-autonomous growth advantage in Nf1+/- astrocytes and suggest that some of the brain pathology in individuals with NF1 might result from reduced, but not absent, NF1 gene function. | lld:pubmed |
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| pubmed-article:11246230 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11246230 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11246230 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11246230 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11246230 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11246230 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11246230 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11246230 | pubmed:issn | 0894-1491 | lld:pubmed |
| pubmed-article:11246230 | pubmed:author | pubmed-author:DonahoeJJ | lld:pubmed |
| pubmed-article:11246230 | pubmed:author | pubmed-author:PellicerAA | lld:pubmed |
| pubmed-article:11246230 | pubmed:author | pubmed-author:ReillyK MKM | lld:pubmed |
| pubmed-article:11246230 | pubmed:author | pubmed-author:GutmannD HDH | lld:pubmed |
| pubmed-article:11246230 | pubmed:author | pubmed-author:BrophySS | lld:pubmed |
| pubmed-article:11246230 | pubmed:author | pubmed-author:CorralTT | lld:pubmed |
| pubmed-article:11246230 | pubmed:author | pubmed-author:BajenaruM LML | lld:pubmed |
| pubmed-article:11246230 | pubmed:copyrightInfo | Copyright 2001 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:11246230 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11246230 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11246230 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:11246230 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11246230 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11246230 | pubmed:pagination | 314-23 | lld:pubmed |
| pubmed-article:11246230 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11246230 | pubmed:meshHeading | pubmed-meshheading:11246230... | lld:pubmed |
| pubmed-article:11246230 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11246230 | pubmed:articleTitle | Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes. | lld:pubmed |
| pubmed-article:11246230 | pubmed:affiliation | Department of Neurology, Washington University School of Medicine, 860 S. Euclid Avenue, St. Louis, MO 63110, USA. | lld:pubmed |
| pubmed-article:11246230 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11246230 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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