Linked Life Data

11241304

Source:http://linkedlifedata.com/resource/pubmed/id/11241304

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:11241304rdf:typepubmed:Citationlld:pubmed
pubmed-article:11241304lifeskim:mentionsumls-concept:C0030705lld:lifeskim
pubmed-article:11241304lifeskim:mentionsumls-concept:C0684249lld:lifeskim
pubmed-article:11241304lifeskim:mentionsumls-concept:C0001418lld:lifeskim
pubmed-article:11241304lifeskim:mentionsumls-concept:C1274040lld:lifeskim
pubmed-article:11241304lifeskim:mentionsumls-concept:C0205217lld:lifeskim
pubmed-article:11241304lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:11241304lifeskim:mentionsumls-concept:C0813622lld:lifeskim
pubmed-article:11241304lifeskim:mentionsumls-concept:C0220901lld:lifeskim
pubmed-article:11241304lifeskim:mentionsumls-concept:C1522609lld:lifeskim
pubmed-article:11241304lifeskim:mentionsumls-concept:C1554112lld:lifeskim
pubmed-article:11241304lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:11241304lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:11241304pubmed:issue1lld:pubmed
pubmed-article:11241304pubmed:dateCreated2001-3-12lld:pubmed
pubmed-article:11241304pubmed:abstractTextThe prognostic value of hyaluronan (HA) was analyzed in a large number of patients (n = 261) with non-small-cell lung cancer (NSCLC) by staining archived tumor samples with a biotinylated HA-specific probe. The level of HA in the tumor cells and surrounding stroma was scored and compared with parallel CD44 stainings, clinicopathological factors and survival data. Adenocarcinomas were characterized by a low percentage of HA-positive cells with low staining intensity compared with squamous-cell and large-cell/anaplastic carcinomas. The HA signal in the peri-tumoral stroma was often higher than that in the uninvolved stroma in all subgroups of NSCLC. CD44 and HA associated with the cancer cells showed a strong positive correlation with each other. In the whole tumor material, dominated by squamous-cell carcinomas (n = 168), recurrences were more often found in cases showing a low percentage of cancer cell-associated HA. However, within the adenocarcinoma subgroup (n = 68), a high percentage of cell-associated HA was correlated with poor tumor differentiation. Also specific for the adenocarcinoma subgroup was the increased number of recurrences in cases with a strong stromal HA signal. In survival analysis of the whole material (n = 189), a low percentage of HA-positive cancer cells was associated with a shortened disease-free survival (DFS) together with stage and tumor type. However, in the subgroup of patients with adenocarcinoma (n = 49), a strong stromal signal for HA predicted poor DFS. The level of HA in the stroma of adenocarcinomas retained its prognostic value in Cox's multivariate analysis. These results indicate that the frequency and intensity of HA has a significant prognostic value in NSCLC, particularly when the histological subtypes are analyzed as separate entities.lld:pubmed
pubmed-article:11241304pubmed:languageenglld:pubmed
pubmed-article:11241304pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11241304pubmed:citationSubsetIMlld:pubmed
pubmed-article:11241304pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11241304pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11241304pubmed:statusMEDLINElld:pubmed
pubmed-article:11241304pubmed:monthJanlld:pubmed
pubmed-article:11241304pubmed:issn0020-7136lld:pubmed
pubmed-article:11241304pubmed:authorpubmed-author:TammiMMlld:pubmed
pubmed-article:11241304pubmed:authorpubmed-author:JohanssonRRlld:pubmed
pubmed-article:11241304pubmed:authorpubmed-author:BöhmJJlld:pubmed
pubmed-article:11241304pubmed:authorpubmed-author:TammiRRlld:pubmed
pubmed-article:11241304pubmed:authorpubmed-author:KosmaV MVMlld:pubmed
pubmed-article:11241304pubmed:authorpubmed-author:ParkkinenJ...lld:pubmed
pubmed-article:11241304pubmed:authorpubmed-author:PirinenRRlld:pubmed
pubmed-article:11241304pubmed:authorpubmed-author:HirvikoskiPPlld:pubmed
pubmed-article:11241304pubmed:authorpubmed-author:HollménSSlld:pubmed
pubmed-article:11241304pubmed:copyrightInfoCopyright 2001 Wiley-Liss, Inc.lld:pubmed
pubmed-article:11241304pubmed:issnTypePrintlld:pubmed
pubmed-article:11241304pubmed:day20lld:pubmed
pubmed-article:11241304pubmed:volume95lld:pubmed
pubmed-article:11241304pubmed:ownerNLMlld:pubmed
pubmed-article:11241304pubmed:authorsCompleteYlld:pubmed
pubmed-article:11241304pubmed:pagination12-7lld:pubmed
pubmed-article:11241304pubmed:dateRevised2007-7-24lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:meshHeadingpubmed-meshheading:11241304...lld:pubmed
pubmed-article:11241304pubmed:year2001lld:pubmed
pubmed-article:11241304pubmed:articleTitlePrognostic value of hyaluronan expression in non-small-cell lung cancer: Increased stromal expression indicates unfavorable outcome in patients with adenocarcinoma.lld:pubmed
pubmed-article:11241304pubmed:affiliationDepartment of Pathology and Forensic Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland.lld:pubmed
pubmed-article:11241304pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11241304pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11241304lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11241304lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11241304lld:pubmed