| pubmed-article:11229403 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11229403 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11229403 | lifeskim:mentions | umls-concept:C0026046 | lld:lifeskim |
| pubmed-article:11229403 | lifeskim:mentions | umls-concept:C0299508 | lld:lifeskim |
| pubmed-article:11229403 | lifeskim:mentions | umls-concept:C1879748 | lld:lifeskim |
| pubmed-article:11229403 | lifeskim:mentions | umls-concept:C1706853 | lld:lifeskim |
| pubmed-article:11229403 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:11229403 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:11229403 | pubmed:issue | 5504 | lld:pubmed |
| pubmed-article:11229403 | pubmed:dateCreated | 2001-3-1 | lld:pubmed |
| pubmed-article:11229403 | pubmed:abstractText | The guanosine triphosphatase Ran stimulates assembly of microtubule asters and spindles in mitotic Xenopus egg extracts. A carboxyl-terminal region of the nuclear-mitotic apparatus protein (NuMA), a nuclear protein required for organizing mitotic spindle poles, mimics Ran's ability to induce asters. This NuMA fragment also specifically interacted with the nuclear transport factor, importin-beta. We show that importin-beta is an inhibitor of microtubule aster assembly in Xenopus egg extracts and that Ran regulates the interaction between importin-beta and NuMA. Importin-beta therefore links NuMA to regulation by Ran. This suggests that similar mechanisms regulate nuclear import during interphase and spindle assembly during mitosis. | lld:pubmed |
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| pubmed-article:11229403 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11229403 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11229403 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11229403 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11229403 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11229403 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:11229403 | pubmed:author | pubmed-author:WildeAA | lld:pubmed |
| pubmed-article:11229403 | pubmed:author | pubmed-author:MooreM SMS | lld:pubmed |
| pubmed-article:11229403 | pubmed:author | pubmed-author:ZhengYY | lld:pubmed |
| pubmed-article:11229403 | pubmed:author | pubmed-author:AdamS ASA | lld:pubmed |
| pubmed-article:11229403 | pubmed:author | pubmed-author:WiestRR | lld:pubmed |
| pubmed-article:11229403 | pubmed:author | pubmed-author:MerdesAA | lld:pubmed |
| pubmed-article:11229403 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11229403 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:11229403 | pubmed:volume | 291 | lld:pubmed |
| pubmed-article:11229403 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11229403 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11229403 | pubmed:pagination | 653-6 | lld:pubmed |
| pubmed-article:11229403 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11229403 | pubmed:meshHeading | pubmed-meshheading:11229403... | lld:pubmed |
| pubmed-article:11229403 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11229403 | pubmed:articleTitle | Role of importin-beta in coupling Ran to downstream targets in microtubule assembly. | lld:pubmed |
| pubmed-article:11229403 | pubmed:affiliation | Department of Embryology, Howard Hughes Medical Institute, Carnegie Institution of Washington, Baltimore, MD 21210, USA. | lld:pubmed |
| pubmed-article:11229403 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11229403 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11229403 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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