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pubmed-article:11215537pubmed:abstractTextIn recent in vivo studies using positron emission tomography (PET) our group demonstrated that the myocardial beta adrenoceptor (betaAR) density is reduced in arrhythmogenic right ventricular cardiomyopathy (ARVC) and idiopathic right ventricular outflow tract tachycardia (RVO-VT) associated with an increased presynaptic catecholamine washout. It was hypothesised that the reduction of myocardial betaAR density is secondary to an increase of local catecholamines in the myocardium resulting from the presynaptic dysfunction since circulating plasma catecholamines were demonstrated to be unchanged in these conditions. To further prove this hypothesis of an organ-limited adrenergic nervous dysfunction of the heart, this study aimed to investigate betaAR density in another thoracic organ, the lung.lld:pubmed
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pubmed-article:11215537pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:11215537pubmed:articleTitlePulmonary beta adrenoceptor density in arrhythmogenic right ventricular cardiomyopathy and idiopathic tachycardia.lld:pubmed
pubmed-article:11215537pubmed:affiliationDepartment of Nuclear Medicine, Münster University, Germany. schafmi@uni-muenster.delld:pubmed
pubmed-article:11215537pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11215537pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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