| pubmed-article:11181160 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11181160 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:11181160 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:11181160 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:11181160 | lifeskim:mentions | umls-concept:C0242656 | lld:lifeskim |
| pubmed-article:11181160 | lifeskim:mentions | umls-concept:C1332700 | lld:lifeskim |
| pubmed-article:11181160 | lifeskim:mentions | umls-concept:C0033413 | lld:lifeskim |
| pubmed-article:11181160 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:11181160 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11181160 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11181160 | pubmed:abstractText | The effect of CC-chemokine receptor 5 (CCR5) promoter polymorphisms on the natural history of human immunodeficiency virus (HIV) disease was studied in 73 HIV-1-infected children. The CCR5(59338-59537) promoter haplotype, CCR5-59029A/G polymorphism, and CCR5Delta32 and CCR2-64I alterations were investigated. After exclusion of carriers of CCR5Delta32 or CCR2-64I, Kaplan-Meier analysis disclosed that children with the P1/P1(59353C,59356C,59402A) genotype progressed faster to disease than did children with other haplotypes (P=.016). When CCR2-64I carriers were included, this effect had borderline significance (P=.065) and was lost when CCR5Delta32 carriers were also considered (P=.387). The P1/P1 effect was strongest early after infection, when progression to disease was mainly associated with CCR5 coreceptor-using viruses. These results indicate that the P1/P1 genotype is predictive of rapid progression in HIV-1-infected children lacking CCR5Delta32 or CCR5-64I alleles. The observation of a linkage disequilibrium between P1 and 59029A might explain the previously reported association between 59029A homozygosity and rapid disease progression. | lld:pubmed |
| pubmed-article:11181160 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11181160 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11181160 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11181160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11181160 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11181160 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11181160 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:11181160 | pubmed:author | pubmed-author:Chieco-Bianch... | lld:pubmed |
| pubmed-article:11181160 | pubmed:author | pubmed-author:De RossiAA | lld:pubmed |
| pubmed-article:11181160 | pubmed:author | pubmed-author:MainardiMM | lld:pubmed |
| pubmed-article:11181160 | pubmed:author | pubmed-author:ZanchettaMM | lld:pubmed |
| pubmed-article:11181160 | pubmed:author | pubmed-author:RugaEE | lld:pubmed |
| pubmed-article:11181160 | pubmed:author | pubmed-author:OmettoLL | lld:pubmed |
| pubmed-article:11181160 | pubmed:author | pubmed-author:BertorelleRR | lld:pubmed |
| pubmed-article:11181160 | pubmed:author | pubmed-author:TognazzoSS | lld:pubmed |
| pubmed-article:11181160 | pubmed:author | pubmed-author:RamponOO | lld:pubmed |
| pubmed-article:11181160 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11181160 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11181160 | pubmed:volume | 183 | lld:pubmed |
| pubmed-article:11181160 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11181160 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11181160 | pubmed:pagination | 814-8 | lld:pubmed |
| pubmed-article:11181160 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11181160 | pubmed:meshHeading | pubmed-meshheading:11181160... | lld:pubmed |
| pubmed-article:11181160 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11181160 | pubmed:articleTitle | Polymorphisms in the CCR5 promoter region influence disease progression in perinatally human immunodeficiency virus type 1-infected children. | lld:pubmed |
| pubmed-article:11181160 | pubmed:affiliation | Department of Oncology and Surgical Sciences, Oncology Section, AIDS Reference Center, Via Gattamelata 64, 35128 Padova, Italy. | lld:pubmed |
| pubmed-article:11181160 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11181160 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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