| pubmed-article:11175354 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11175354 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11175354 | lifeskim:mentions | umls-concept:C1706474 | lld:lifeskim |
| pubmed-article:11175354 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:11175354 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:11175354 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:11175354 | lifeskim:mentions | umls-concept:C2003905 | lld:lifeskim |
| pubmed-article:11175354 | pubmed:issue | 54 | lld:pubmed |
| pubmed-article:11175354 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11175354 | pubmed:abstractText | The tumour suppressor IRF-1 is a transcription factor involved in the induction of apoptosis in several in vitro systems. Post-lactational involution of the mammary gland is characterized by extensive apoptosis of the epithelial cells. We have previously shown that signal transducer and activator of transcription (Stat) 3 drives apoptosis and involution in the mouse mammary gland. Since one of the downstream targets of the Stat signalling pathway is IRF-1, we have used IRF-1 knockout mice to address the potential role of this transcription factor in involution. Surprisingly, in the absence of IRF-1 significantly higher numbers of apoptotic cells were found in involuting glands at 48 h compared to control glands. In addition, the alveolar structure in IRF-1 null mammary glands had collapsed whereas in control glands the alveoli remained intact and distended. However, by 72 h control and null glands were morphologically similar suggesting that IRF-1 suppresses apoptosis only during the early, reversible, stage of involution. This suggests a survival role for IRF-1 in mammary epithelia and demonstrates a novel role for IRF-1 in vivo--suppression of premature epithelial apoptosis during mammary gland involution. | lld:pubmed |
| pubmed-article:11175354 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11175354 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175354 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11175354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11175354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175354 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11175354 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11175354 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:11175354 | pubmed:author | pubmed-author:WatsonC JCJ | lld:pubmed |
| pubmed-article:11175354 | pubmed:author | pubmed-author:ClarkeA RAR | lld:pubmed |
| pubmed-article:11175354 | pubmed:author | pubmed-author:ChapmanR SRS | lld:pubmed |
| pubmed-article:11175354 | pubmed:author | pubmed-author:FlintD JDJ | lld:pubmed |
| pubmed-article:11175354 | pubmed:author | pubmed-author:TonnerEE | lld:pubmed |
| pubmed-article:11175354 | pubmed:author | pubmed-author:BöseGG | lld:pubmed |
| pubmed-article:11175354 | pubmed:author | pubmed-author:LourencoP CPC | lld:pubmed |
| pubmed-article:11175354 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11175354 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:11175354 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:11175354 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11175354 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11175354 | pubmed:pagination | 6386-91 | lld:pubmed |
| pubmed-article:11175354 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11175354 | pubmed:meshHeading | pubmed-meshheading:11175354... | lld:pubmed |
| pubmed-article:11175354 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11175354 | pubmed:articleTitle | A novel role for IRF-1 as a suppressor of apoptosis. | lld:pubmed |
| pubmed-article:11175354 | pubmed:affiliation | Cancer Research Campaign (CRC) Laboratories, Department of Pathology, University of Edinburgh, Medical School, Edinburgh, EH8 9AG, UK. | lld:pubmed |
| pubmed-article:11175354 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11175354 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16362 | entrezgene:pubmed | pubmed-article:11175354 | lld:entrezgene |
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