| pubmed-article:11161976 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11161976 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:11161976 | lifeskim:mentions | umls-concept:C0259931 | lld:lifeskim |
| pubmed-article:11161976 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:11161976 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11161976 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11161976 | pubmed:abstractText | Mechanisms that protect most high-risk HIV-1 seronegative (HRSN) persons are not well understood. Among hemophiliacs from the Multicenter Hemophilia Cohort Study who remained HIV-1 seronegative despite a high (94%) risk for acquisition of HIV-1 infection, only 7/43 were homozygous for the protective CCR5 Delta32 polymorphism. Among the remainder, neither CCR5 density nor beta-chemokine production, nor in vitro susceptibility to infection with the HIV-1 isolate JR-FL could distinguish HRSN hemophiliacs from healthy controls. When compared to lymphocytes of healthy controls not at risk for HIV-1 infection, diminished spontaneous lymphocyte proliferation was seen in lymphocytes of HRSN hemophiliacs as well as in lymphocytes of hemophiliacs not at risk for HIV-1 infection. Surprisingly sera/plasmas obtained from high-risk HIV-1 seropositve hemophiliacs prior to seroconversion more often contained alloreactive antibodies than date-matched sera/plasmas obtained from HRSN hemophiliacs. Thus alloreactivity may predispose to acquisition of HIV-1 infection after parenteral exposure. | lld:pubmed |
| pubmed-article:11161976 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11161976 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11161976 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11161976 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11161976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11161976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11161976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11161976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11161976 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11161976 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11161976 | pubmed:issn | 1521-6616 | lld:pubmed |
| pubmed-article:11161976 | pubmed:author | pubmed-author:WhiteG CGC2nd | lld:pubmed |
| pubmed-article:11161976 | pubmed:author | pubmed-author:KesslerCC | lld:pubmed |
| pubmed-article:11161976 | pubmed:author | pubmed-author:EysterM EME | lld:pubmed |
| pubmed-article:11161976 | pubmed:author | pubmed-author:AledortLL | lld:pubmed |
| pubmed-article:11161976 | pubmed:author | pubmed-author:ZimmermanPP | lld:pubmed |
| pubmed-article:11161976 | pubmed:author | pubmed-author:HilgartnerMM | lld:pubmed |
| pubmed-article:11161976 | pubmed:author | pubmed-author:O'BrienT RTR | lld:pubmed |
| pubmed-article:11161976 | pubmed:author | pubmed-author:KonkleB ABA | lld:pubmed |
| pubmed-article:11161976 | pubmed:author | pubmed-author:GoedertJ JJJ | lld:pubmed |
| pubmed-article:11161976 | pubmed:author | pubmed-author:LedermanM MMM | lld:pubmed |
| pubmed-article:11161976 | pubmed:author | pubmed-author:PurvisS FSF | lld:pubmed |
| pubmed-article:11161976 | pubmed:author | pubmed-author:MeyersonHH | lld:pubmed |
| pubmed-article:11161976 | pubmed:author | pubmed-author:SalkowitzJ... | lld:pubmed |
| pubmed-article:11161976 | pubmed:copyrightInfo | Copyright 2000 Academic Press. | lld:pubmed |
| pubmed-article:11161976 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11161976 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:11161976 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11161976 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11161976 | pubmed:pagination | 200-11 | lld:pubmed |
| pubmed-article:11161976 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11161976 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11161976 | pubmed:articleTitle | Characterization of high-risk HIV-1 seronegative hemophiliacs. | lld:pubmed |
| pubmed-article:11161976 | pubmed:affiliation | Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio, 44106, USA. | lld:pubmed |
| pubmed-article:11161976 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11161976 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11161976 | pubmed:publicationType | Multicenter Study | lld:pubmed |
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