| pubmed-article:11115400 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11115400 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:11115400 | lifeskim:mentions | umls-concept:C0033640 | lld:lifeskim |
| pubmed-article:11115400 | lifeskim:mentions | umls-concept:C1334085 | lld:lifeskim |
| pubmed-article:11115400 | lifeskim:mentions | umls-concept:C1708411 | lld:lifeskim |
| pubmed-article:11115400 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:11115400 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:11115400 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:11115400 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:11115400 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:11115400 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:11115400 | pubmed:issue | Pt 1 | lld:pubmed |
| pubmed-article:11115400 | pubmed:dateCreated | 2001-1-26 | lld:pubmed |
| pubmed-article:11115400 | pubmed:abstractText | Members of the interferon-induced class of nuclear factors possess a putative CcN motif, comparable with that within proteins such as the simian virus 40 large tumour antigen (T-ag), which confers phosphorylation-mediated regulation of nuclear-localization sequence (NLS)-dependent nuclear import. Here we examine the functionality of the interferon-induced factor 16 (IFI 16) CcN motif, demonstrating its ability to target a heterologous protein to the nucleus, and to be phosphorylated specifically by the CcN-motif-phosphorylating protein kinase CK2 (CK2). The IFI 16 NLS, however, has novel properties, conferring ATP-dependent nuclear import completely independent of cytosolic factors, as well as binding to nuclear components. The IFI 16 NLS is not recognized with high affinity by the NLS-binding importin heterodimer, and transport mediated by it is insensitive to non-hydrolysable GTP analogues. The IFI 16 NLS thus mediates nuclear import through a pathway completely distinct from that of conventional NLSs, such as that of T-ag, but intriguingly resembling that of the NLS of the HIV-1 transactivator protein Tat. Since the IFI 16 CK2 site enhances nuclear import through facilitating binding to nuclear components, this represents a novel mechanism by which the site regulates nuclear-protein import, and constitutes a difference between the IFI 16 and Tat NLSs that may be of importance in the immune response. | lld:pubmed |
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| pubmed-article:11115400 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11115400 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115400 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11115400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11115400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115400 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11115400 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11115400 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:11115400 | pubmed:author | pubmed-author:DawsonMM | lld:pubmed |
| pubmed-article:11115400 | pubmed:author | pubmed-author:JansD ADA | lld:pubmed |
| pubmed-article:11115400 | pubmed:author | pubmed-author:JohnstoneR... | lld:pubmed |
| pubmed-article:11115400 | pubmed:author | pubmed-author:TrapaniJ AJA | lld:pubmed |
| pubmed-article:11115400 | pubmed:author | pubmed-author:XiaoC YCY | lld:pubmed |
| pubmed-article:11115400 | pubmed:author | pubmed-author:BriggsL JLJ | lld:pubmed |
| pubmed-article:11115400 | pubmed:author | pubmed-author:ElliotR MRM | lld:pubmed |
| pubmed-article:11115400 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11115400 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11115400 | pubmed:volume | 353 | lld:pubmed |
| pubmed-article:11115400 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11115400 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11115400 | pubmed:pagination | 69-77 | lld:pubmed |
| pubmed-article:11115400 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
