| pubmed-article:11078524 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11078524 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:11078524 | lifeskim:mentions | umls-concept:C0023689 | lld:lifeskim |
| pubmed-article:11078524 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:11078524 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:11078524 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:11078524 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
| pubmed-article:11078524 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:11078524 | pubmed:dateCreated | 2000-12-12 | lld:pubmed |
| pubmed-article:11078524 | pubmed:abstractText | Parkinson's disease is a common neurodegenerative disorder in which familial-linked genes have provided novel insights into the pathogenesis of this disorder. Mutations in Parkin, a ring-finger-containing protein of unknown function, are implicated in the pathogenesis of autosomal recessive familial Parkinson's disease. Here, we show that Parkin binds to the E2 ubiquitin-conjugating human enzyme 8 (UbcH8) through its C-terminal ring-finger. Parkin has ubiquitin-protein ligase activity in the presence of UbcH8. Parkin also ubiquitinates itself and promotes its own degradation. We also identify and show that the synaptic vesicle-associated protein, CDCrel-1, interacts with Parkin through its ring-finger domains. Furthermore, Parkin ubiquitinates and promotes the degradation of CDCrel-1. Familial-linked mutations disrupt the ubiquitin-protein ligase function of Parkin and impair Parkin and CDCrel-1 degradation. These results suggest that Parkin functions as an E3 ubiquitin-protein ligase through its ring domains and that it may control protein levels via ubiquitination. The loss of Parkin's ubiquitin-protein ligase function in familial-linked mutations suggests that this may be the cause of familial autosomal recessive Parkinson's disease. | lld:pubmed |
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| pubmed-article:11078524 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11078524 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11078524 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11078524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11078524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11078524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11078524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11078524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11078524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11078524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11078524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11078524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11078524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11078524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11078524 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11078524 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11078524 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:11078524 | pubmed:author | pubmed-author:HuangHH | lld:pubmed |
| pubmed-article:11078524 | pubmed:author | pubmed-author:ZhangYY | lld:pubmed |
| pubmed-article:11078524 | pubmed:author | pubmed-author:ChungK KKK | lld:pubmed |
| pubmed-article:11078524 | pubmed:author | pubmed-author:DawsonT MTM | lld:pubmed |
| pubmed-article:11078524 | pubmed:author | pubmed-author:GalMM | lld:pubmed |
| pubmed-article:11078524 | pubmed:author | pubmed-author:DawsonV LVL | lld:pubmed |
| pubmed-article:11078524 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11078524 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:11078524 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:11078524 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11078524 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11078524 | pubmed:pagination | 13354-9 | lld:pubmed |
| pubmed-article:11078524 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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