| pubmed-article:11060011 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11060011 | lifeskim:mentions | umls-concept:C1515669 | lld:lifeskim |
| pubmed-article:11060011 | lifeskim:mentions | umls-concept:C1417898 | lld:lifeskim |
| pubmed-article:11060011 | lifeskim:mentions | umls-concept:C1517773 | lld:lifeskim |
| pubmed-article:11060011 | lifeskim:mentions | umls-concept:C1864009 | lld:lifeskim |
| pubmed-article:11060011 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:11060011 | lifeskim:mentions | umls-concept:C1522002 | lld:lifeskim |
| pubmed-article:11060011 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:11060011 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:11060011 | lifeskim:mentions | umls-concept:C0034115 | lld:lifeskim |
| pubmed-article:11060011 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:11060011 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:11060011 | lifeskim:mentions | umls-concept:C0449830 | lld:lifeskim |
| pubmed-article:11060011 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:11060011 | lifeskim:mentions | umls-concept:C1504308 | lld:lifeskim |
| pubmed-article:11060011 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:11060011 | pubmed:dateCreated | 2000-11-29 | lld:pubmed |
| pubmed-article:11060011 | pubmed:abstractText | Human TAP is implicated in mRNA nuclear export and is used by simian type D retroviruses to export their unspliced genomic RNA to the cytoplasm of the host cell. We have determined the crystal structure of the minimal TAP fragment that binds the constitutive transport element (CTE) of retroviral RNAs. Unexpectedly, we find the fragment consists of a ribonucleoprotein (RNP) domain, which is not identifiable by its sequence, and a leucine-rich repeat (LRR) domain. The non-canonical RNP domain functions as the general RNA-binding portion of the fragment. The LRR domain is required in cis to the RNP domain for CTE RNA binding. The structural and biochemical properties of the domains point to a remarkable similarity with the U2B"(RNP)-U2A'(LRR) spliceosomal heterodimer. Our in vitro and in vivo functional studies using structure-based mutants suggest that a phylogenetically conserved surface of the LRR domain of TAP may have different roles in the export of viral and cellular RNAs. | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11060011 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11060011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060011 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11060011 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11060011 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:11060011 | pubmed:author | pubmed-author:FernandezEE | lld:pubmed |
| pubmed-article:11060011 | pubmed:author | pubmed-author:ConteAA | lld:pubmed |
| pubmed-article:11060011 | pubmed:author | pubmed-author:IzaurraldeEE | lld:pubmed |
| pubmed-article:11060011 | pubmed:author | pubmed-author:LikerEE | lld:pubmed |
| pubmed-article:11060011 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11060011 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11060011 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:11060011 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11060011 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11060011 | pubmed:pagination | 5587-98 | lld:pubmed |
| pubmed-article:11060011 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11060011 | pubmed:meshHeading | pubmed-meshheading:11060011... | lld:pubmed |
| pubmed-article:11060011 | pubmed:meshHeading | pubmed-meshheading:11060011... | lld:pubmed |
| pubmed-article:11060011 | pubmed:meshHeading | pubmed-meshheading:11060011... | lld:pubmed |
| pubmed-article:11060011 | pubmed:meshHeading | pubmed-meshheading:11060011... | lld:pubmed |
| pubmed-article:11060011 | pubmed:meshHeading | pubmed-meshheading:11060011... | lld:pubmed |
| pubmed-article:11060011 | pubmed:meshHeading | pubmed-meshheading:11060011... | lld:pubmed |
| pubmed-article:11060011 | pubmed:meshHeading | pubmed-meshheading:11060011... | lld:pubmed |
| pubmed-article:11060011 | pubmed:meshHeading | pubmed-meshheading:11060011... | lld:pubmed |
| pubmed-article:11060011 | pubmed:meshHeading | pubmed-meshheading:11060011... | lld:pubmed |
| pubmed-article:11060011 | pubmed:meshHeading | pubmed-meshheading:11060011... | lld:pubmed |
| pubmed-article:11060011 | pubmed:meshHeading | pubmed-meshheading:11060011... | lld:pubmed |
| pubmed-article:11060011 | pubmed:meshHeading | pubmed-meshheading:11060011... | lld:pubmed |
| pubmed-article:11060011 | pubmed:meshHeading | pubmed-meshheading:11060011... | lld:pubmed |
| pubmed-article:11060011 | pubmed:meshHeading | pubmed-meshheading:11060011... | lld:pubmed |
| pubmed-article:11060011 | pubmed:meshHeading | pubmed-meshheading:11060011... | lld:pubmed |
| pubmed-article:11060011 | pubmed:meshHeading | pubmed-meshheading:11060011... | lld:pubmed |
| pubmed-article:11060011 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11060011 | pubmed:articleTitle | The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain. | lld:pubmed |
