| pubmed-article:11052806 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11052806 | lifeskim:mentions | umls-concept:C0033262 | lld:lifeskim |
| pubmed-article:11052806 | lifeskim:mentions | umls-concept:C0012091 | lld:lifeskim |
| pubmed-article:11052806 | lifeskim:mentions | umls-concept:C0014898 | lld:lifeskim |
| pubmed-article:11052806 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:11052806 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:11052806 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:11052806 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:11052806 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:11052806 | pubmed:dateCreated | 2000-11-7 | lld:pubmed |
| pubmed-article:11052806 | pubmed:abstractText | Despite its widespread use, diclofenac has gastrointestinal liabilities common to nonsteroidal antiinflammatory drugs (NSAIDs) that might be reduced by concomitant administration of a gastrointestinal cytoprotectant such as nitric oxide (NO). A series of novel diclofenac esters containing a nitrosothiol (-S-NO) moiety as a NO donor functionality has been synthesized and evaluated in vivo for bioavailability, pharmacological activity, and gastric irritation. All S-NO-diclofenac derivatives acted as orally bioavailable prodrugs, producing significant levels of diclofenac in plasma within 15 min after oral administration to mice. At equimolar oral doses, S-NO-diclofenac derivatives (20a-21b) displayed rat antiinflammatory and analgesic activities comparable to those of diclofenac in the carrageenan-induced paw edema test and the mouse phenylbenzoquinone-induced writhing test, respectively. All tested S-NO-diclofenac derivatives (20a-21b) were gastric-sparing in that they elicited markedly fewer stomach lesions as compared to the stomach lesions caused by a high equimolar dose of diclofenac in the rat. Nitrosothiol esters of diclofenac comprise a novel class of NO-donating compounds having therapeutic potential as nonsteroidal antiinflammatory agents with an enhanced gastric safety profile. | lld:pubmed |
| pubmed-article:11052806 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11052806 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11052806 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11052806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11052806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11052806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11052806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11052806 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11052806 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11052806 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:11052806 | pubmed:author | pubmed-author:LettsL GLG | lld:pubmed |
| pubmed-article:11052806 | pubmed:author | pubmed-author:ChenLL | lld:pubmed |
| pubmed-article:11052806 | pubmed:author | pubmed-author:TamS WSW | lld:pubmed |
| pubmed-article:11052806 | pubmed:author | pubmed-author:FangXX | lld:pubmed |
| pubmed-article:11052806 | pubmed:author | pubmed-author:SahiJ SJS | lld:pubmed |
| pubmed-article:11052806 | pubmed:author | pubmed-author:GarveyD SDS | lld:pubmed |
| pubmed-article:11052806 | pubmed:author | pubmed-author:JaneroD RDR | lld:pubmed |
| pubmed-article:11052806 | pubmed:author | pubmed-author:SchroederJ... | lld:pubmed |
| pubmed-article:11052806 | pubmed:author | pubmed-author:BandarageU... | lld:pubmed |
| pubmed-article:11052806 | pubmed:author | pubmed-author:GlavinAA | lld:pubmed |
| pubmed-article:11052806 | pubmed:author | pubmed-author:MercerG JGJ | lld:pubmed |
| pubmed-article:11052806 | pubmed:author | pubmed-author:ShumwayM JMJ | lld:pubmed |
| pubmed-article:11052806 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11052806 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:11052806 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:11052806 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11052806 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11052806 | pubmed:pagination | 4005-16 | lld:pubmed |
| pubmed-article:11052806 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11052806 | pubmed:meshHeading | pubmed-meshheading:11052806... | lld:pubmed |
| pubmed-article:11052806 | pubmed:meshHeading | pubmed-meshheading:11052806... | lld:pubmed |
| pubmed-article:11052806 | pubmed:meshHeading | pubmed-meshheading:11052806... | lld:pubmed |
| pubmed-article:11052806 | pubmed:meshHeading | pubmed-meshheading:11052806... | lld:pubmed |
| pubmed-article:11052806 | pubmed:meshHeading | pubmed-meshheading:11052806... | lld:pubmed |
| pubmed-article:11052806 | pubmed:meshHeading | pubmed-meshheading:11052806... | lld:pubmed |
| pubmed-article:11052806 | pubmed:meshHeading | pubmed-meshheading:11052806... | lld:pubmed |
| pubmed-article:11052806 | pubmed:meshHeading | pubmed-meshheading:11052806... | lld:pubmed |
| pubmed-article:11052806 | pubmed:meshHeading | pubmed-meshheading:11052806... | lld:pubmed |
| pubmed-article:11052806 | pubmed:meshHeading | pubmed-meshheading:11052806... | lld:pubmed |
| pubmed-article:11052806 | pubmed:meshHeading | pubmed-meshheading:11052806... | lld:pubmed |
| pubmed-article:11052806 | pubmed:meshHeading | pubmed-meshheading:11052806... | lld:pubmed |
| pubmed-article:11052806 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11052806 | pubmed:articleTitle | Nitrosothiol esters of diclofenac: synthesis and pharmacological characterization as gastrointestinal-sparing prodrugs. | lld:pubmed |
| pubmed-article:11052806 | pubmed:affiliation | NitroMed, Inc., 12 Oak Park Drive, Bedford, Massachusetts 01730, USA. ubandarage@nitromed.com | lld:pubmed |
| pubmed-article:11052806 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11052806 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:11052806 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11052806 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11052806 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11052806 | lld:pubmed |
