Linked Life Data

11043414

Source:http://linkedlifedata.com/resource/pubmed/id/11043414

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pubmed-article:11043414pubmed:dateCreated2001-1-22lld:pubmed
pubmed-article:11043414pubmed:abstractTextAt fertilisation in mammals the sperm initiates a series of Ca2+ oscillations that activate development. One theory of signalling at fertilisation suggests that the sperm contains a soluble protein factor that causes these Ca2+ oscillations by entering the egg after sperm-egg membrane fusion. This theory is supported by the finding that, in some species, injection of sperm protein extracts into eggs triggers a pattern of Ca2+ oscillations similar to those seen at fertilisation. So far, all the direct evidence for a sperm factor has been based upon the injection of soluble proteins from mature sperm. Here, we demonstrate that injection of mRNA extracted from hamster spermatogenic cells also leads to generation of prolonged Ca2+ oscillations in mouse eggs. The ability of spermatogenic cell mRNA to induce Ca2+ oscillations is dependent upon translation into protein and also appears to be specific to spermatogenic cells since injection of mRNA isolated from somatic tissues into eggs was ineffective. These data support the hypothesis that sperm contain a soluble, cytosolic protein factor that induces Ca2+ oscillations in eggs at fertilisation. These data are discussed in the light of our recent findings that suggest that the sperm factor possesses a phospholipase C activity.lld:pubmed
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pubmed-article:11043414pubmed:authorpubmed-author:SwankLLlld:pubmed
pubmed-article:11043414pubmed:authorpubmed-author:DayN ANAlld:pubmed
pubmed-article:11043414pubmed:authorpubmed-author:ParringtonJJlld:pubmed
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pubmed-article:11043414pubmed:volume92lld:pubmed
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pubmed-article:11043414pubmed:pagination267-75lld:pubmed
pubmed-article:11043414pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11043414pubmed:articleTitleThe soluble mammalian sperm factor protein that triggers Ca2+ oscillations in eggs: evidence for expression of mRNA(s) coding for sperm factor protein(s) in spermatogenic cells.lld:pubmed
pubmed-article:11043414pubmed:affiliationDepartment of Anatomy and Developmental Biology, University College London, UK. j.parrington@ucl.ac.uklld:pubmed
pubmed-article:11043414pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11043414pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed