| pubmed-article:11016667 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11016667 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11016667 | lifeskim:mentions | umls-concept:C0018593 | lld:lifeskim |
| pubmed-article:11016667 | lifeskim:mentions | umls-concept:C0205341 | lld:lifeskim |
| pubmed-article:11016667 | lifeskim:mentions | umls-concept:C0162351 | lld:lifeskim |
| pubmed-article:11016667 | lifeskim:mentions | umls-concept:C0205253 | lld:lifeskim |
| pubmed-article:11016667 | lifeskim:mentions | umls-concept:C0805586 | lld:lifeskim |
| pubmed-article:11016667 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11016667 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11016667 | pubmed:dateCreated | 2001-1-16 | lld:pubmed |
| pubmed-article:11016667 | pubmed:abstractText | An immediate reaction was investigated during repeated challenge testing for contact hypersensitivity to dinitrofluorobenzene (DNFB) in BALB/c mice. The mice were sensitized to DNFB on back skin and repeatedly challenged with the same hapten on the left ear at 1 week intervals. The ear after the 5th challenge showed biphasic responses which consisted of an immediate and a delayed-type reaction. The reactions were hapten specific. Mast cell-deficient WBB6F1 W/WV mice did not show any immediate reaction, while congenic normal mice showed both immediate and delayed-type reactions. Histologically, numerous dermal mast cells were found in the left ear of repeatedly challenged BALB/c and WBB6F1 normal mice, while there were few mast cells in the ear of WBB6F1 W/WV mice. Anti-DNP IgE antibodies were detected in BALB/c, WBB6F1 normal and W/WV mice after repeated challenge with DNFB. Intradermal injection of anti-IgE antibodies in the repeatedly DNFB-challenged ear elicited an immediate reaction. These results suggest that immediate contact hypersensitivity develops through the production of anti-DNP IgE antibodies and an increase in dermal mast cells after repeated challenge with DNFB. | lld:pubmed |
| pubmed-article:11016667 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11016667 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11016667 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11016667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11016667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11016667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11016667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11016667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11016667 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11016667 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11016667 | pubmed:issn | 0105-1873 | lld:pubmed |
| pubmed-article:11016667 | pubmed:author | pubmed-author:KitaniSS | lld:pubmed |
| pubmed-article:11016667 | pubmed:author | pubmed-author:YanoNN | lld:pubmed |
| pubmed-article:11016667 | pubmed:author | pubmed-author:YamayaKK | lld:pubmed |
| pubmed-article:11016667 | pubmed:author | pubmed-author:NatsuakiMM | lld:pubmed |
| pubmed-article:11016667 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11016667 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:11016667 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11016667 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11016667 | pubmed:pagination | 267-72 | lld:pubmed |
| pubmed-article:11016667 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11016667 | pubmed:meshHeading | pubmed-meshheading:11016667... | lld:pubmed |
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| pubmed-article:11016667 | pubmed:meshHeading | pubmed-meshheading:11016667... | lld:pubmed |
| pubmed-article:11016667 | pubmed:meshHeading | pubmed-meshheading:11016667... | lld:pubmed |
| pubmed-article:11016667 | pubmed:meshHeading | pubmed-meshheading:11016667... | lld:pubmed |
| pubmed-article:11016667 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11016667 | pubmed:articleTitle | Immediate contact hypersensitivity induced by repeated hapten challenge in mice. | lld:pubmed |
| pubmed-article:11016667 | pubmed:affiliation | Department of Dermatology, Hyogo College of Medicine, Nishinomiya, Japan. | lld:pubmed |
| pubmed-article:11016667 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11016667 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11016667 | lld:pubmed |
