| pubmed-article:11000224 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11000224 | lifeskim:mentions | umls-concept:C0004422 | lld:lifeskim |
| pubmed-article:11000224 | lifeskim:mentions | umls-concept:C1079230 | lld:lifeskim |
| pubmed-article:11000224 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:11000224 | lifeskim:mentions | umls-concept:C0034802 | lld:lifeskim |
| pubmed-article:11000224 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:11000224 | lifeskim:mentions | umls-concept:C0162768 | lld:lifeskim |
| pubmed-article:11000224 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:11000224 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:11000224 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:11000224 | lifeskim:mentions | umls-concept:C0086022 | lld:lifeskim |
| pubmed-article:11000224 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:11000224 | lifeskim:mentions | umls-concept:C1705099 | lld:lifeskim |
| pubmed-article:11000224 | lifeskim:mentions | umls-concept:C0442335 | lld:lifeskim |
| pubmed-article:11000224 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:11000224 | pubmed:dateCreated | 2000-10-12 | lld:pubmed |
| pubmed-article:11000224 | pubmed:abstractText | We have previously described an approach that employs retroviral receptor-ligand bridge proteins to target retroviral vectors to specific cell types. To determine whether targeted retroviral entry can also be achieved using a retroviral receptor-single-chain antibody bridge protein, the TVA-MR1 fusion protein was generated. TVA-MR1 is comprised of the extracellular domain of the TVA receptor for subgroup A avian leukosis viruses (ALV-A), fused to the MR1 single-chain antibody that binds specifically to EGFRvIII, a tumor-specific form of the epidermal growth factor receptor. We show that TVA-MR1 binds specifically to a murine version of EGFRvIII and promotes ALV-A entry selectively into cells that express this cell surface marker. These studies demonstrate that it is possible to target retroviral vectors to specific cell types through the use of a retroviral receptor-single-chain antibody fusion protein. | lld:pubmed |
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| pubmed-article:11000224 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11000224 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11000224 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11000224 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11000224 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11000224 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11000224 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:11000224 | pubmed:author | pubmed-author:YoungJ AJA | lld:pubmed |
| pubmed-article:11000224 | pubmed:author | pubmed-author:CarterB SBS | lld:pubmed |
| pubmed-article:11000224 | pubmed:author | pubmed-author:MulliganR CRC | lld:pubmed |
| pubmed-article:11000224 | pubmed:author | pubmed-author:NiedermanT... | lld:pubmed |
| pubmed-article:11000224 | pubmed:author | pubmed-author:SnitkovskySS | lld:pubmed |
| pubmed-article:11000224 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11000224 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:11000224 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11000224 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11000224 | pubmed:pagination | 9540-5 | lld:pubmed |
| pubmed-article:11000224 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
