| pubmed-article:10980284 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10980284 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10980284 | lifeskim:mentions | umls-concept:C0081937 | lld:lifeskim |
| pubmed-article:10980284 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:10980284 | lifeskim:mentions | umls-concept:C0184511 | lld:lifeskim |
| pubmed-article:10980284 | lifeskim:mentions | umls-concept:C0178665 | lld:lifeskim |
| pubmed-article:10980284 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:10980284 | lifeskim:mentions | umls-concept:C1256369 | lld:lifeskim |
| pubmed-article:10980284 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:10980284 | pubmed:dateCreated | 2000-10-26 | lld:pubmed |
| pubmed-article:10980284 | pubmed:abstractText | We explored whether inhibition of the enzyme dipeptidyl peptidase IV (DPP IV) increases endogenous levels of glucagon-like peptide-1 (GLP-1) and improves glucose tolerance and insulin secretion in mice. Glucose (150 mg) was administered through a gastric gavage with or without the inhibitor of dipeptidyl peptidase IV, valine-pyrrolidide (100 micromol/kg), in high-fat fed glucose intolerant or control C57BL/6J mice. The increase in plasma GLP-1 after gastric glucose was potentiated by dipeptidyl peptidase IV inhibition (P<0.05). Valine-pyrrolidide also potentiated the plasma insulin response to gastric glucose and improved the glucose tolerance in both groups of mice (P<0.001). In contrast, valine-pyrrolidide did not affect glucose-stimulated insulin secretion from isolated islets. This suggests that valine-pyrrolidide improves insulin secretion and glucose tolerance through indirect action, probably through augmentation of levels of GLP-1 and other incretin hormones. Therefore, inhibition of dipeptidyl peptidase IV activity is feasible to exploit as a treatment for glucose intolerance and type 2 diabetes. | lld:pubmed |
| pubmed-article:10980284 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10980284 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10980284 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10980284 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10980284 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10980284 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10980284 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10980284 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10980284 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10980284 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10980284 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10980284 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:10980284 | pubmed:author | pubmed-author:HolstJ JJJ | lld:pubmed |
| pubmed-article:10980284 | pubmed:author | pubmed-author:AhrénBB | lld:pubmed |
| pubmed-article:10980284 | pubmed:author | pubmed-author:MårtenssonHH | lld:pubmed |
| pubmed-article:10980284 | pubmed:author | pubmed-author:BalkanBB | lld:pubmed |
| pubmed-article:10980284 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10980284 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10980284 | pubmed:volume | 404 | lld:pubmed |
| pubmed-article:10980284 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10980284 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10980284 | pubmed:pagination | 239-45 | lld:pubmed |
| pubmed-article:10980284 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:10980284 | pubmed:meshHeading | pubmed-meshheading:10980284... | lld:pubmed |
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| pubmed-article:10980284 | pubmed:meshHeading | pubmed-meshheading:10980284... | lld:pubmed |
| pubmed-article:10980284 | pubmed:meshHeading | pubmed-meshheading:10980284... | lld:pubmed |
| pubmed-article:10980284 | pubmed:meshHeading | pubmed-meshheading:10980284... | lld:pubmed |
| pubmed-article:10980284 | pubmed:meshHeading | pubmed-meshheading:10980284... | lld:pubmed |
| pubmed-article:10980284 | pubmed:meshHeading | pubmed-meshheading:10980284... | lld:pubmed |
| pubmed-article:10980284 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10980284 | pubmed:articleTitle | Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice. | lld:pubmed |
| pubmed-article:10980284 | pubmed:affiliation | Department of Medicine, Malmö University Hospital, Lund University, S-205 02, Malmö, Sweden. bo.ahren@medforsk.mas.lu.se | lld:pubmed |
| pubmed-article:10980284 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10980284 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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