| pubmed-article:10973946 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10973946 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:10973946 | lifeskim:mentions | umls-concept:C0022131 | lld:lifeskim |
| pubmed-article:10973946 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:10973946 | lifeskim:mentions | umls-concept:C0017710 | lld:lifeskim |
| pubmed-article:10973946 | lifeskim:mentions | umls-concept:C0020392 | lld:lifeskim |
| pubmed-article:10973946 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:10973946 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:10973946 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:10973946 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:10973946 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:10973946 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:10973946 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10973946 | pubmed:issue | 45 | lld:pubmed |
| pubmed-article:10973946 | pubmed:dateCreated | 2000-11-27 | lld:pubmed |
| pubmed-article:10973946 | pubmed:abstractText | Metabolic transformation of glucocorticoid hormones constitutes a determinant of their cell-specific effects. The most important reaction for this class of steroids is the reversible C11 keto/beta-hydroxyl conversion between receptor-binding 11beta-OH steroids and the nonbinding 11-oxo compounds, carried out by 11beta-hydroxysteroid dehydrogenases (11beta-HSDs). In this study, we determined the role of glucocorticoid conversion by 11beta-HSD in pancreatic islets and its function in the regulation of insulin release. Pancreatic islets isolated from ob/ob mice display type 1 11beta-hydroxysteroid dehydrogenase activity, i.e. in intact cells the reductive reaction prevails, leading from dehydrocorticosterone to corticosterone. Expression of type 1 11beta-HSD mRNA was detected by reverse transcriptase-polymerase chain reaction in islets isolated from ob/ob mice and also from human tissue. Incubation of beta-cells in the presence of 11-dehydrocorticosterone leads to a dose-dependent inhibition of insulin release, indicating cellular activation of 11-dehydrocorticosterone to the receptor ligand, further confirmed by reporter gene assays. Inhibition of 11beta-HSD activity by carbenoxolone reverses inhibition of insulin release. The presence of 11beta-HSD in islets supports the concept that reactivation of inert circulating hormone precursors in a cell-specific manner plays a major role in glucocorticoid physiology in rodents and man. | lld:pubmed |
| pubmed-article:10973946 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10973946 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10973946 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10973946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10973946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10973946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10973946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10973946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10973946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10973946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10973946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10973946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10973946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10973946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10973946 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10973946 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:10973946 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10973946 | pubmed:author | pubmed-author:EfendicSS | lld:pubmed |
| pubmed-article:10973946 | pubmed:author | pubmed-author:OkretSS | lld:pubmed |
| pubmed-article:10973946 | pubmed:author | pubmed-author:MårtenssonEE | lld:pubmed |
| pubmed-article:10973946 | pubmed:author | pubmed-author:KhanAA | lld:pubmed |
| pubmed-article:10973946 | pubmed:author | pubmed-author:JörnvallHH | lld:pubmed |
| pubmed-article:10973946 | pubmed:author | pubmed-author:HuluNN | lld:pubmed |
| pubmed-article:10973946 | pubmed:author | pubmed-author:OppermannU... | lld:pubmed |
| pubmed-article:10973946 | pubmed:author | pubmed-author:DavaniBB | lld:pubmed |
| pubmed-article:10973946 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10973946 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:10973946 | pubmed:volume | 275 | lld:pubmed |
| pubmed-article:10973946 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10973946 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10973946 | pubmed:pagination | 34841-4 | lld:pubmed |
| pubmed-article:10973946 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:10973946 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10973946 | pubmed:articleTitle | Type 1 11beta -hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets. | lld:pubmed |
| pubmed-article:10973946 | pubmed:affiliation | Department of Molecular Medicine, Karolinska Hospital, S 171 76 Stockholm, Sweden. | lld:pubmed |
| pubmed-article:10973946 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10973946 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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