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pubmed-article:10956408pubmed:abstractTextWe investigated by immunocytochemistry the expression of the Ca(2+) binding protein S100A2 in 62 cases of laryngeal squamous-cell carcinoma (SCC). S100A2 was detected in 18/19 (95%) low-grade tumors and in 22/43 (51%) high-grade tumors, which were partially keratinizing. The remaining 21/43 (49%) high-grade tumors were non-keratinizing, anaplastic tumors and clearly S100A2-negative. In normal laryngeal squamous epithelium and in laryngeal SCC, S100A2 expression was strictly associated with that of cytokeratins 14 (P = 0.0002) and 17 (P = 0.0021), suggesting an association of S100A2 expression and cell commitment to squamous differentiation. A correlation was found between S100A2 tumor positivity and longer relapse-free (P = 0.0005) and overall (P = 0.0095) survival.lld:pubmed
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pubmed-article:10956408pubmed:copyrightInfoCopyright 2000 Wiley-Liss, Inc.lld:pubmed
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pubmed-article:10956408pubmed:articleTitlePrognostic significance of the Ca(2+) binding protein S100A2 in laryngeal squamous-cell carcinoma.lld:pubmed
pubmed-article:10956408pubmed:affiliationInstitute of Pathology, Università Cattolica del S. Cuore, Rome, Italy. ibiap@rm.unicatt.itlld:pubmed
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