Linked Life Data

10950839

Source:http://linkedlifedata.com/resource/pubmed/id/10950839

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10950839rdf:typepubmed:Citationlld:pubmed
pubmed-article:10950839lifeskim:mentionsumls-concept:C0034721lld:lifeskim
pubmed-article:10950839lifeskim:mentionsumls-concept:C0034693lld:lifeskim
pubmed-article:10950839lifeskim:mentionsumls-concept:C1704242lld:lifeskim
pubmed-article:10950839lifeskim:mentionsumls-concept:C0312418lld:lifeskim
pubmed-article:10950839lifeskim:mentionsumls-concept:C1280500lld:lifeskim
pubmed-article:10950839lifeskim:mentionsumls-concept:C1413167lld:lifeskim
pubmed-article:10950839lifeskim:mentionsumls-concept:C1533691lld:lifeskim
pubmed-article:10950839lifeskim:mentionsumls-concept:C1550147lld:lifeskim
pubmed-article:10950839lifeskim:mentionsumls-concept:C0036667lld:lifeskim
pubmed-article:10950839pubmed:issue3lld:pubmed
pubmed-article:10950839pubmed:dateCreated2000-9-19lld:pubmed
pubmed-article:10950839pubmed:abstractTextTo prevent the blood-borne interference and reflex actions via neighboring organs and the central nervous system, the study was conducted in an in vitro isolated stomach-gastric vagus nerve preparation obtained from overnight-fasted, urethan-anesthetized rats. Afferent unit action potentials were recorded from the gastric branch of the vagus nerve. The left gastric artery was catheterized for intra-arterial injection. In vitro we found that 1) 55/70 gastric vagal afferents (GVAs) were polymodal, responding to CCK-8 and mechanical stimuli, 13 were mechanoreceptive, and 2 were CCK-responsive; 2) sequential or randomized intra-arterial injections of CCK-8 (0.1-200 pmol) dose-dependently increased firing rate and reached the peak rate at 100 pmol; 3) the action was suppressed by CCK-A (Devazepide) but not by CCK-B (L-365,260) receptor antagonist; 4) neither antagonist blocked the mechanosensitivity of GVA fibers. These results are consistent with corresponding in vivo well-documented findings. Histological data indicate that the layered structure of the stomach wall was preserved in vitro for 6-8 h. Based on these results, it seems reasonable to use the in vitro preparation for conducting a study that is usually difficult to be performed in vivo. For instance, because there was no blood supply in vitro, the composition of the interstitial fluid, i.e., the ambient nerve terminals, can be better controlled and influenced by intra-arterial injection of a defined solution. Here we report that acutely changing the ambient CCK level by a conditioning stimulus (a preceding intra-arterial injection of increasing doses of CCK-8) reduced the CCK sensitivity of GVA terminals to a subsequent test stimulus (a constant dose of CCK-8 intra-arterial injection).lld:pubmed
pubmed-article:10950839pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10950839pubmed:languageenglld:pubmed
pubmed-article:10950839pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10950839pubmed:citationSubsetIMlld:pubmed
pubmed-article:10950839pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10950839pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10950839pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10950839pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10950839pubmed:statusMEDLINElld:pubmed
pubmed-article:10950839pubmed:monthSeplld:pubmed
pubmed-article:10950839pubmed:issn0193-1849lld:pubmed
pubmed-article:10950839pubmed:authorpubmed-author:WeiJ YJYlld:pubmed
pubmed-article:10950839pubmed:authorpubmed-author:WangY HYHlld:pubmed
pubmed-article:10950839pubmed:issnTypePrintlld:pubmed
pubmed-article:10950839pubmed:volume279lld:pubmed
pubmed-article:10950839pubmed:ownerNLMlld:pubmed
pubmed-article:10950839pubmed:authorsCompleteYlld:pubmed
pubmed-article:10950839pubmed:paginationE695-706lld:pubmed
pubmed-article:10950839pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:10950839pubmed:meshHeadingpubmed-meshheading:10950839...lld:pubmed
pubmed-article:10950839pubmed:meshHeadingpubmed-meshheading:10950839...lld:pubmed
pubmed-article:10950839pubmed:meshHeadingpubmed-meshheading:10950839...lld:pubmed
pubmed-article:10950839pubmed:meshHeadingpubmed-meshheading:10950839...lld:pubmed
pubmed-article:10950839pubmed:meshHeadingpubmed-meshheading:10950839...lld:pubmed
pubmed-article:10950839pubmed:meshHeadingpubmed-meshheading:10950839...lld:pubmed
pubmed-article:10950839pubmed:meshHeadingpubmed-meshheading:10950839...lld:pubmed
pubmed-article:10950839pubmed:meshHeadingpubmed-meshheading:10950839...lld:pubmed
pubmed-article:10950839pubmed:meshHeadingpubmed-meshheading:10950839...lld:pubmed
pubmed-article:10950839pubmed:meshHeadingpubmed-meshheading:10950839...lld:pubmed
pubmed-article:10950839pubmed:meshHeadingpubmed-meshheading:10950839...lld:pubmed
pubmed-article:10950839pubmed:meshHeadingpubmed-meshheading:10950839...lld:pubmed
pubmed-article:10950839pubmed:meshHeadingpubmed-meshheading:10950839...lld:pubmed
pubmed-article:10950839pubmed:meshHeadingpubmed-meshheading:10950839...lld:pubmed
pubmed-article:10950839pubmed:meshHeadingpubmed-meshheading:10950839...lld:pubmed
pubmed-article:10950839pubmed:meshHeadingpubmed-meshheading:10950839...lld:pubmed
pubmed-article:10950839pubmed:year2000lld:pubmed
pubmed-article:10950839pubmed:articleTitleEffect of CCK pretreatment on the CCK sensitivity of rat polymodal gastric vagal afferent in vitro.lld:pubmed
pubmed-article:10950839pubmed:affiliationDigestive Diseases Division, Department of Medicine, Center for Ulcer Research and Education/Digestive Diseases Research Center and Brain Research Institute, University of California Los Angeles School of Medicine, 90095, USA.lld:pubmed
pubmed-article:10950839pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10950839pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950839lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950839lld:pubmed