Linked Life Data

10950769

Source:http://linkedlifedata.com/resource/pubmed/id/10950769

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10950769rdf:typepubmed:Citationlld:pubmed
pubmed-article:10950769lifeskim:mentionsumls-concept:C0019704lld:lifeskim
pubmed-article:10950769lifeskim:mentionsumls-concept:C0205466lld:lifeskim
pubmed-article:10950769lifeskim:mentionsumls-concept:C0087111lld:lifeskim
pubmed-article:10950769lifeskim:mentionsumls-concept:C0033607lld:lifeskim
pubmed-article:10950769lifeskim:mentionsumls-concept:C0013203lld:lifeskim
pubmed-article:10950769lifeskim:mentionsumls-concept:C1704632lld:lifeskim
pubmed-article:10950769lifeskim:mentionsumls-concept:C0871261lld:lifeskim
pubmed-article:10950769lifeskim:mentionsumls-concept:C2911692lld:lifeskim
pubmed-article:10950769lifeskim:mentionsumls-concept:C1706817lld:lifeskim
pubmed-article:10950769lifeskim:mentionsumls-concept:C0681842lld:lifeskim
pubmed-article:10950769pubmed:issue3lld:pubmed
pubmed-article:10950769pubmed:dateCreated2000-11-3lld:pubmed
pubmed-article:10950769pubmed:abstractTextThe extent to which human immunodeficiency virus (HIV) type 1 drug resistance compromises therapeutic efficacy is intimately tied to drug potency and exposure. Most HIV-1 protease inhibitors maintain in vivo trough levels above their human serum protein binding-corrected IC(95) values for wild-type HIV-1. However, these troughs are well below corrected IC(95) values for protease inhibitor-resistant viruses from patients experiencing virologic failure of indinavir and/or nelfinavir. This suggests that none of the single protease inhibitors would be effective after many cases of protease inhibitor failure. However, saquinavir, amprenavir, and indinavir blood levels are increased substantially when each is coadministered with ritonavir, with 12-h troughs exceeding corrected wild-type IC(95) by 2-, 7-, and 28-79-fold, respectively. These indinavir and amprenavir troughs exceed IC(95) for most protease inhibitor-resistant viruses tested. This suggests that twice-daily indinavir-ritonavir and, to a lesser extent, amprenavir-ritonavir may be effective for many patients with viruses resistant to protease inhibitors.lld:pubmed
pubmed-article:10950769pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10950769pubmed:languageenglld:pubmed
pubmed-article:10950769pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10950769pubmed:citationSubsetAIMlld:pubmed
pubmed-article:10950769pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10950769pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10950769pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10950769pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10950769pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10950769pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10950769pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10950769pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10950769pubmed:statusMEDLINElld:pubmed
pubmed-article:10950769pubmed:monthSeplld:pubmed
pubmed-article:10950769pubmed:issn0022-1899lld:pubmed
pubmed-article:10950769pubmed:authorpubmed-author:EminiE AEAlld:pubmed
pubmed-article:10950769pubmed:authorpubmed-author:SchleifW AWAlld:pubmed
pubmed-article:10950769pubmed:authorpubmed-author:CondraJ HJHlld:pubmed
pubmed-article:10950769pubmed:authorpubmed-author:PetropoulosC...lld:pubmed
pubmed-article:10950769pubmed:authorpubmed-author:ZiermannRRlld:pubmed
pubmed-article:10950769pubmed:authorpubmed-author:ShivaprakashM...lld:pubmed
pubmed-article:10950769pubmed:issnTypePrintlld:pubmed
pubmed-article:10950769pubmed:volume182lld:pubmed
pubmed-article:10950769pubmed:ownerNLMlld:pubmed
pubmed-article:10950769pubmed:authorsCompleteYlld:pubmed
pubmed-article:10950769pubmed:pagination758-65lld:pubmed
pubmed-article:10950769pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:10950769pubmed:meshHeadingpubmed-meshheading:10950769...lld:pubmed
pubmed-article:10950769pubmed:meshHeadingpubmed-meshheading:10950769...lld:pubmed
pubmed-article:10950769pubmed:meshHeadingpubmed-meshheading:10950769...lld:pubmed
pubmed-article:10950769pubmed:meshHeadingpubmed-meshheading:10950769...lld:pubmed
pubmed-article:10950769pubmed:meshHeadingpubmed-meshheading:10950769...lld:pubmed
pubmed-article:10950769pubmed:meshHeadingpubmed-meshheading:10950769...lld:pubmed
pubmed-article:10950769pubmed:meshHeadingpubmed-meshheading:10950769...lld:pubmed
pubmed-article:10950769pubmed:meshHeadingpubmed-meshheading:10950769...lld:pubmed
pubmed-article:10950769pubmed:meshHeadingpubmed-meshheading:10950769...lld:pubmed
pubmed-article:10950769pubmed:meshHeadingpubmed-meshheading:10950769...lld:pubmed
pubmed-article:10950769pubmed:meshHeadingpubmed-meshheading:10950769...lld:pubmed
pubmed-article:10950769pubmed:meshHeadingpubmed-meshheading:10950769...lld:pubmed
pubmed-article:10950769pubmed:meshHeadingpubmed-meshheading:10950769...lld:pubmed
pubmed-article:10950769pubmed:meshHeadingpubmed-meshheading:10950769...lld:pubmed
pubmed-article:10950769pubmed:meshHeadingpubmed-meshheading:10950769...lld:pubmed
pubmed-article:10950769pubmed:meshHeadingpubmed-meshheading:10950769...lld:pubmed
pubmed-article:10950769pubmed:year2000lld:pubmed
pubmed-article:10950769pubmed:articleTitleDrug resistance and predicted virologic responses to human immunodeficiency virus type 1 protease inhibitor therapy.lld:pubmed
pubmed-article:10950769pubmed:affiliationDepartment of Antiviral Research, Merck Research Laboratories, West Point, PA 19486, USA. jon_condra@merck.comlld:pubmed
pubmed-article:10950769pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10950769pubmed:publicationTypeClinical Triallld:pubmed
pubmed-article:10950769pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950769lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950769lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950769lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950769lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950769lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950769lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950769lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950769lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950769lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950769lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950769lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950769lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950769lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950769lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950769lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950769lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10950769lld:pubmed