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pubmed-article:10939333pubmed:abstractTextCone pedicles, the synaptic terminals of cone photoreceptors, are connected in the macaque monkey retina to several hundred postsynaptic dendrites. Using light and electron microscopy, we found underneath each cone pedicle a laminated distribution of dendritic processes of bipolar and horizontal cells. Superimposed were three strata of glutamate receptor (GluR) aggregates, including a novel layer of glutamate receptors clustered at desmosome-like junctions. They are, most likely, postsynaptic densities on horizontal cell dendrites. GABA(A) and GABA(C) receptors are aggregated on bipolar cell dendrites in a narrow band underneath the cone pedicle. Glutamate released from cone pedicles and GABA released from horizontal cell dendrites act not only through direct synaptic contacts but also (more so) through diffusion to the appropriate receptors.lld:pubmed
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pubmed-article:10939333pubmed:articleTitleThe cone pedicle, a complex synapse in the retina.lld:pubmed
pubmed-article:10939333pubmed:affiliationNeuroanatomische Abteilung, Max-Planck-Institut für Hirnforschung, Frankfurt/Main, Germany.lld:pubmed
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