Linked Life Data

10918594

Source:http://linkedlifedata.com/resource/pubmed/id/10918594

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10918594rdf:typepubmed:Citationlld:pubmed
pubmed-article:10918594lifeskim:mentionsumls-concept:C0007634lld:lifeskim
pubmed-article:10918594lifeskim:mentionsumls-concept:C0537969lld:lifeskim
pubmed-article:10918594lifeskim:mentionsumls-concept:C1706474lld:lifeskim
pubmed-article:10918594lifeskim:mentionsumls-concept:C0553580lld:lifeskim
pubmed-article:10918594lifeskim:mentionsumls-concept:C0162638lld:lifeskim
pubmed-article:10918594lifeskim:mentionsumls-concept:C0031715lld:lifeskim
pubmed-article:10918594lifeskim:mentionsumls-concept:C0036720lld:lifeskim
pubmed-article:10918594lifeskim:mentionsumls-concept:C0086597lld:lifeskim
pubmed-article:10918594lifeskim:mentionsumls-concept:C0205263lld:lifeskim
pubmed-article:10918594lifeskim:mentionsumls-concept:C1879547lld:lifeskim
pubmed-article:10918594pubmed:issue30lld:pubmed
pubmed-article:10918594pubmed:dateCreated2000-8-18lld:pubmed
pubmed-article:10918594pubmed:abstractTextFour human cell lines derived from Ewing's sarcoma, EW-7, EW-1, COH and ORS, were investigated to establish the effects of human recombinant interferon-alpha2a and human recombinant interferon-beta on cell proliferation and apoptosis. All four cell lines were much more sensitive to the antiproliferative effects of IFN-beta than of IFN-alpha. Analysis of the early signals triggered by IFN-alpha and IFN-beta demonstrated that the two IFNs were similarly effective in inducing tyrosine phosphorylation of the Jak-1 and Tyk-2 kinases and the transcription factors Stat-1 and Stat-2. Interestingly, an additional rapid phosphorylation of Stat-1 on serine was observed after IFN-beta treatment, with concomitant activation of p38 mitogen-activated protein kinase. In these cells, Stat-1 Ser727 phosphorylation in response to IFN-beta was found to be impaired by p38 MAPkinase inhibitor (SB203580). IFN-beta induced the formation of the Interferon Stimulated Gene Factor 3 complex more efficiently than IFN-alpha, as well as sustained induction of IRF-1, which may account for its greater induction of 2'5'oligo(A)synthetase and greater inhibition of cell proliferation. IFN-beta, but not IFN-alpha, induced apoptosis in wild-type p53 EW-7 and COH cell lines, but not in the mutated p53 EW-1 or ORS cell lines. The apoptosis induced by IFN-beta in EW-7 and COH cell lines appeared to be mediated by IRF-1 and involved the activation of caspase-7. Ectopic expression of IRF-1 induced apoptosis in all four cell lines which correlated with the activation of caspase-7 and with the downregulation of the Bcl-2 oncoprotein, as observed for IFN-beta-induced apoptosis in parental EW-7 and COH cell lines.lld:pubmed
pubmed-article:10918594pubmed:languageenglld:pubmed
pubmed-article:10918594pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:citationSubsetIMlld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10918594pubmed:statusMEDLINElld:pubmed
pubmed-article:10918594pubmed:monthJullld:pubmed
pubmed-article:10918594pubmed:issn0950-9232lld:pubmed
pubmed-article:10918594pubmed:authorpubmed-author:WietzerbinJJlld:pubmed
pubmed-article:10918594pubmed:authorpubmed-author:DelattreOOlld:pubmed
pubmed-article:10918594pubmed:authorpubmed-author:HiscottJJlld:pubmed
pubmed-article:10918594pubmed:authorpubmed-author:SancéauJJlld:pubmed
pubmed-article:10918594pubmed:issnTypePrintlld:pubmed
pubmed-article:10918594pubmed:day13lld:pubmed
pubmed-article:10918594pubmed:volume19lld:pubmed
pubmed-article:10918594pubmed:ownerNLMlld:pubmed
pubmed-article:10918594pubmed:authorsCompleteYlld:pubmed
pubmed-article:10918594pubmed:pagination3372-83lld:pubmed
pubmed-article:10918594pubmed:dateRevised2011-11-17lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:meshHeadingpubmed-meshheading:10918594...lld:pubmed
pubmed-article:10918594pubmed:year2000lld:pubmed
pubmed-article:10918594pubmed:articleTitleIFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7.lld:pubmed
pubmed-article:10918594pubmed:affiliationINSERM U 365, Institut Curie, Paris, France.lld:pubmed
pubmed-article:10918594pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10918594pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:3456entrezgene:pubmedpubmed-article:10918594lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10918594lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10918594lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10918594lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10918594lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10918594lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10918594lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10918594lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10918594lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10918594lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10918594lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10918594lld:pubmed
More...