| pubmed-article:10894262 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10894262 | lifeskim:mentions | umls-concept:C0206745 | lld:lifeskim |
| pubmed-article:10894262 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:10894262 | lifeskim:mentions | umls-concept:C0927232 | lld:lifeskim |
| pubmed-article:10894262 | lifeskim:mentions | umls-concept:C0206307 | lld:lifeskim |
| pubmed-article:10894262 | lifeskim:mentions | umls-concept:C1517499 | lld:lifeskim |
| pubmed-article:10894262 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10894262 | pubmed:dateCreated | 2000-10-10 | lld:pubmed |
| pubmed-article:10894262 | pubmed:abstractText | Canavan disease (CD) is an autosomal recessive leukodystrophy characterized by deficiency of aspartoacylase (ASPA) and increased levels of N-acetylaspartic acid (NAA) in brain and body fluids, severe mental retardation and early death. Gene therapy has been attempted in a number of children with CD. The lack of an animal model has been a limiting factor in developing vectors for the treatment of CD. This paper reports the successful creation of a knock-out mouse for Canavan disease that can be used for gene transfer. | lld:pubmed |
| pubmed-article:10894262 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10894262 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10894262 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10894262 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10894262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10894262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10894262 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10894262 | pubmed:issn | 1099-498X | lld:pubmed |
| pubmed-article:10894262 | pubmed:author | pubmed-author:MatalonRR | lld:pubmed |
| pubmed-article:10894262 | pubmed:author | pubmed-author:CampbellG AGA | lld:pubmed |
| pubmed-article:10894262 | pubmed:author | pubmed-author:WeiJJ | lld:pubmed |
| pubmed-article:10894262 | pubmed:author | pubmed-author:SkinnerH BHB | lld:pubmed |
| pubmed-article:10894262 | pubmed:author | pubmed-author:TyringS KSK | lld:pubmed |
| pubmed-article:10894262 | pubmed:author | pubmed-author:CeciJ DJD | lld:pubmed |
| pubmed-article:10894262 | pubmed:author | pubmed-author:SzucsSS | lld:pubmed |
| pubmed-article:10894262 | pubmed:author | pubmed-author:EzellE LEL | lld:pubmed |
| pubmed-article:10894262 | pubmed:author | pubmed-author:PlattK AKA | lld:pubmed |
| pubmed-article:10894262 | pubmed:author | pubmed-author:QuastM JMJ | lld:pubmed |
| pubmed-article:10894262 | pubmed:author | pubmed-author:NehlsMM | lld:pubmed |
| pubmed-article:10894262 | pubmed:author | pubmed-author:RadyP LPL | lld:pubmed |
| pubmed-article:10894262 | pubmed:author | pubmed-author:SurendranSS | lld:pubmed |
| pubmed-article:10894262 | pubmed:author | pubmed-author:MatalonKK | lld:pubmed |
| pubmed-article:10894262 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10894262 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:10894262 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10894262 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10894262 | pubmed:pagination | 165-75 | lld:pubmed |
| pubmed-article:10894262 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10894262 | pubmed:meshHeading | pubmed-meshheading:10894262... | lld:pubmed |
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| pubmed-article:10894262 | pubmed:meshHeading | pubmed-meshheading:10894262... | lld:pubmed |
| pubmed-article:10894262 | pubmed:meshHeading | pubmed-meshheading:10894262... | lld:pubmed |
| pubmed-article:10894262 | pubmed:meshHeading | pubmed-meshheading:10894262... | lld:pubmed |
| pubmed-article:10894262 | pubmed:meshHeading | pubmed-meshheading:10894262... | lld:pubmed |
| pubmed-article:10894262 | pubmed:meshHeading | pubmed-meshheading:10894262... | lld:pubmed |
| pubmed-article:10894262 | pubmed:meshHeading | pubmed-meshheading:10894262... | lld:pubmed |
| pubmed-article:10894262 | pubmed:meshHeading | pubmed-meshheading:10894262... | lld:pubmed |
| pubmed-article:10894262 | pubmed:meshHeading | pubmed-meshheading:10894262... | lld:pubmed |
| pubmed-article:10894262 | pubmed:meshHeading | pubmed-meshheading:10894262... | lld:pubmed |
| pubmed-article:10894262 | pubmed:articleTitle | Knock-out mouse for Canavan disease: a model for gene transfer to the central nervous system. | lld:pubmed |
| pubmed-article:10894262 | pubmed:affiliation | Department of Pediatrics, Children's Hospital, UTMB Galveston, TX 77555-0359, USA. rmatalon@utmb.edu | lld:pubmed |
| pubmed-article:10894262 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10894262 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10894262 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:11484 | entrezgene:pubmed | pubmed-article:10894262 | lld:entrezgene |
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