| pubmed-article:10889464 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10889464 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:10889464 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10889464 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:10889464 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:10889464 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:10889464 | lifeskim:mentions | umls-concept:C0205463 | lld:lifeskim |
| pubmed-article:10889464 | lifeskim:mentions | umls-concept:C1880371 | lld:lifeskim |
| pubmed-article:10889464 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:10889464 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10889464 | pubmed:dateCreated | 2000-11-16 | lld:pubmed |
| pubmed-article:10889464 | pubmed:abstractText | The extracellular Ca(2+) (Ca(2+)(o))-sensing receptor (CaR) critically influences Ca(2+)(o) homeostasis by regulating parathyroid hormone (PTH) secretion and renal Ca(2+) handling. Moreover, its expression in intestinal and bone cells suggests roles in all of the organs involved in maintaining systemic Ca(2+)(o) homeostasis. This G-protein coupled receptor is also expressed in a wide variety of additional cells throughout the body. While our understanding of its role(s) outside of the system governing Ca(2+)(o) metabolism remains rudimentary, the CaR will probably emerge as a versatile regulator of diverse cellular functions, including proliferation, differentiation, apoptosis, gene expression and maintenance of membrane potential. Finally, the recently developed, "calcimimetic" CaR activators, exemplified by a NPS R-467 and NPS R-568, provide novel approaches to treating diseases that previously had no effective medical therapies: topic likewise covered in this review. | lld:pubmed |
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| pubmed-article:10889464 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10889464 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10889464 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10889464 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10889464 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10889464 | pubmed:issn | 0898-6568 | lld:pubmed |
| pubmed-article:10889464 | pubmed:author | pubmed-author:BrownE MEM | lld:pubmed |
| pubmed-article:10889464 | pubmed:author | pubmed-author:Chattopadhyay... | lld:pubmed |
| pubmed-article:10889464 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10889464 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:10889464 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10889464 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10889464 | pubmed:pagination | 361-6 | lld:pubmed |
| pubmed-article:10889464 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10889464 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10889464 | pubmed:articleTitle | Cellular "sensing" of extracellular calcium (Ca(2+)(o)): emerging roles in regulating diverse physiological functions. | lld:pubmed |
| pubmed-article:10889464 | pubmed:affiliation | Endocrine-Hypertension Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. nchattopadhyay@rics.bwh.harvard.edu | lld:pubmed |
| pubmed-article:10889464 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10889464 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10889464 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10889464 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:10889464 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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