| pubmed-article:10882079 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10882079 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10882079 | lifeskim:mentions | umls-concept:C0525013 | lld:lifeskim |
| pubmed-article:10882079 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:10882079 | lifeskim:mentions | umls-concept:C0011519 | lld:lifeskim |
| pubmed-article:10882079 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:10882079 | lifeskim:mentions | umls-concept:C0017373 | lld:lifeskim |
| pubmed-article:10882079 | lifeskim:mentions | umls-concept:C0005221 | lld:lifeskim |
| pubmed-article:10882079 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:10882079 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:10882079 | lifeskim:mentions | umls-concept:C1546856 | lld:lifeskim |
| pubmed-article:10882079 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10882079 | pubmed:dateCreated | 2000-7-17 | lld:pubmed |
| pubmed-article:10882079 | pubmed:abstractText | We have generated mice with a targeted deletion of the beta-globin locus control region (LCR). Mice homozygous for the deletion die early in embryogenesis but can be rescued with a YAC containing the human beta-globin locus. After germline passage, deletion of the LCR leads to a severe reduction in expression of all mouse beta-like globin genes, but no alteration in the developmental specificity of expression. Furthermore, a DNase I-sensitive "open" chromatin conformation of the locus is established and maintained. Thus, the dominant role of the LCR in the native locus is to confer high-level transcription, and elements elsewhere in the locus are sufficient to establish and maintain an open conformation and to confer developmentally regulated globin gene expression. | lld:pubmed |
| pubmed-article:10882079 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10882079 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10882079 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10882079 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10882079 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10882079 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10882079 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10882079 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10882079 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10882079 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10882079 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10882079 | pubmed:issn | 1097-2765 | lld:pubmed |
| pubmed-article:10882079 | pubmed:author | pubmed-author:GroudineMM | lld:pubmed |
| pubmed-article:10882079 | pubmed:author | pubmed-author:BenderM AMA | lld:pubmed |
| pubmed-article:10882079 | pubmed:author | pubmed-author:CloseJJ | lld:pubmed |
| pubmed-article:10882079 | pubmed:author | pubmed-author:BulgerMM | lld:pubmed |
| pubmed-article:10882079 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10882079 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:10882079 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10882079 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10882079 | pubmed:pagination | 387-93 | lld:pubmed |
| pubmed-article:10882079 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10882079 | pubmed:meshHeading | pubmed-meshheading:10882079... | lld:pubmed |
| pubmed-article:10882079 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10882079 | pubmed:articleTitle | Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region. | lld:pubmed |
| pubmed-article:10882079 | pubmed:affiliation | Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. mbender@fhcrc.org | lld:pubmed |
| pubmed-article:10882079 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10882079 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10882079 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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