| pubmed-article:10875273 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10875273 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:10875273 | lifeskim:mentions | umls-concept:C0029418 | lld:lifeskim |
| pubmed-article:10875273 | lifeskim:mentions | umls-concept:C0222660 | lld:lifeskim |
| pubmed-article:10875273 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:10875273 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:10875273 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:10875273 | lifeskim:mentions | umls-concept:C1317149 | lld:lifeskim |
| pubmed-article:10875273 | lifeskim:mentions | umls-concept:C2247140 | lld:lifeskim |
| pubmed-article:10875273 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:10875273 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:10875273 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:10875273 | pubmed:dateCreated | 2000-7-20 | lld:pubmed |
| pubmed-article:10875273 | pubmed:abstractText | Insulin-like growth factor I (IGF-I) is an important growth factor for bone, yet the mechanisms that mediate its anabolic activity in the skeleton are poorly understood. To examine the effects of locally produced IGF-I in bone in vivo, we targeted expression IGF-I to osteoblasts of transgenic mice using a human osteocalcin promoter. The IGF-I transgene was expressed in bone osteoblasts in OC-IGF-I transgenic mice at high levels in the absence of any change in serum IGF-I levels, or of total body growth. Bone formation rate at the distal femur in 3-week-old OC-IGF-I transgenic mice was approximately twice that of controls. By 6 weeks, bone mineral density as measured by dual energy x-ray, and quantitative computed tomography was significantly greater in OC-IGF-I transgenic mice compared with controls. Histomorphometric measurements revealed a marked (30%) increase femoral cancellous bone volume in the OC-IGF-I transgenic mice, but no change in the total number of osteoblasts or osteoclasts. Transgenic mice also demonstrated an increase in the osteocyte lacunea occupancy, suggesting that IGF-I may extend the osteocyte life span. We conclude that IGF-I produced locally in bone osteoblasts exerts its anabolic effect primarily by increasing the activity of resident osteoblasts. | lld:pubmed |
| pubmed-article:10875273 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10875273 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10875273 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10875273 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10875273 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10875273 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10875273 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10875273 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10875273 | pubmed:issn | 0013-7227 | lld:pubmed |
| pubmed-article:10875273 | pubmed:author | pubmed-author:NakayamaTT | lld:pubmed |
| pubmed-article:10875273 | pubmed:author | pubmed-author:ClemensT LTL | lld:pubmed |
| pubmed-article:10875273 | pubmed:author | pubmed-author:PikeJ WJW | lld:pubmed |
| pubmed-article:10875273 | pubmed:author | pubmed-author:MallucheH HHH | lld:pubmed |
| pubmed-article:10875273 | pubmed:author | pubmed-author:FabioG PGP | lld:pubmed |
| pubmed-article:10875273 | pubmed:author | pubmed-author:ChernausekS... | lld:pubmed |
| pubmed-article:10875273 | pubmed:author | pubmed-author:ZhaiMM | lld:pubmed |
| pubmed-article:10875273 | pubmed:author | pubmed-author:DonahueL RLR | lld:pubmed |
| pubmed-article:10875273 | pubmed:author | pubmed-author:Monier-Fauger... | lld:pubmed |
| pubmed-article:10875273 | pubmed:author | pubmed-author:RosenC JCJ | lld:pubmed |
| pubmed-article:10875273 | pubmed:author | pubmed-author:GengZZ | lld:pubmed |
| pubmed-article:10875273 | pubmed:author | pubmed-author:LangubM CMC | lld:pubmed |
| pubmed-article:10875273 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10875273 | pubmed:volume | 141 | lld:pubmed |
| pubmed-article:10875273 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10875273 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10875273 | pubmed:pagination | 2674-82 | lld:pubmed |
| pubmed-article:10875273 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10875273 | pubmed:meshHeading | pubmed-meshheading:10875273... | lld:pubmed |
| pubmed-article:10875273 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10875273 | pubmed:articleTitle | Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation. | lld:pubmed |
| pubmed-article:10875273 | pubmed:affiliation | Department of Medicine, University of Cincinnati College of Medicine, Ohio 45267, USA. | lld:pubmed |
| pubmed-article:10875273 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10875273 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10875273 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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