| pubmed-article:10869443 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10869443 | lifeskim:mentions | umls-concept:C0456909 | lld:lifeskim |
| pubmed-article:10869443 | lifeskim:mentions | umls-concept:C1522424 | lld:lifeskim |
| pubmed-article:10869443 | lifeskim:mentions | umls-concept:C0231335 | lld:lifeskim |
| pubmed-article:10869443 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:10869443 | lifeskim:mentions | umls-concept:C0035339 | lld:lifeskim |
| pubmed-article:10869443 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:10869443 | lifeskim:mentions | umls-concept:C0035323 | lld:lifeskim |
| pubmed-article:10869443 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:10869443 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:10869443 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:10869443 | pubmed:dateCreated | 2000-8-24 | lld:pubmed |
| pubmed-article:10869443 | pubmed:abstractText | Mutations in the retinal pigment epithelium gene encoding RPE65 are a cause of the incurable early-onset recessive human retinal degenerations known as Leber congenital amaurosis. Rpe65-deficient mice, a model of Leber congenital amaurosis, have no rod photopigment and severely impaired rod physiology. We analyzed retinoid flow in this model and then intervened by using oral 9-cis-retinal, attempting to bypass the biochemical block caused by the genetic abnormality. Within 48 h, there was formation of rod photopigment and dramatic improvement in rod physiology, thus demonstrating that mechanism-based pharmacological intervention has the potential to restore vision in otherwise incurable genetic retinal degenerations. | lld:pubmed |
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| pubmed-article:10869443 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10869443 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10869443 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10869443 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10869443 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10869443 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10869443 | pubmed:author | pubmed-author:JacobsonS GSG | lld:pubmed |
| pubmed-article:10869443 | pubmed:author | pubmed-author:StoneE MEM | lld:pubmed |
| pubmed-article:10869443 | pubmed:author | pubmed-author:PalczewskiKK | lld:pubmed |
| pubmed-article:10869443 | pubmed:author | pubmed-author:PittlerS JSJ | lld:pubmed |
| pubmed-article:10869443 | pubmed:author | pubmed-author:CideciyanA... | lld:pubmed |
| pubmed-article:10869443 | pubmed:author | pubmed-author:GuY ZYZ | lld:pubmed |
| pubmed-article:10869443 | pubmed:author | pubmed-author:Van HooserJ... | lld:pubmed |
| pubmed-article:10869443 | pubmed:author | pubmed-author:AlemanT STS | lld:pubmed |
| pubmed-article:10869443 | pubmed:author | pubmed-author:KuksaVV | lld:pubmed |
| pubmed-article:10869443 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10869443 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:10869443 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:10869443 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10869443 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10869443 | pubmed:pagination | 8623-8 | lld:pubmed |
| pubmed-article:10869443 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
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