| pubmed-article:10860725 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10860725 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
| pubmed-article:10860725 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:10860725 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:10860725 | lifeskim:mentions | umls-concept:C0001407 | lld:lifeskim |
| pubmed-article:10860725 | lifeskim:mentions | umls-concept:C0038999 | lld:lifeskim |
| pubmed-article:10860725 | lifeskim:mentions | umls-concept:C0444626 | lld:lifeskim |
| pubmed-article:10860725 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:10860725 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:10860725 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10860725 | pubmed:dateCreated | 2000-7-7 | lld:pubmed |
| pubmed-article:10860725 | pubmed:abstractText | Crystal structure of a DNA.RNA hybrid, d(CTCCTCTTC).r(gaagagagag), with an adenine bulge in the polypurine RNA strand was determined at 2.3 A resolution. The structure was solved by the molecular replacement method and refined to a final R-factor of 19.9% (Rfree 22.2%). The hybrid duplex crystallized in the space group I222 with unit cell dimensions, a = 46.66 A, b = 47.61 A and c = 54.05 A, and adopts the A-form conformation. All RNA and DNA sugars are in the C3'-endo conformation, the glycosyl angles in anti conformation and the majority of the C4'-C5' torsion angles in g+ except two trans angles, in conformity with the C3'-endo rigid nucleotide hypothesis. The adenine bulge is looped out and it is also in the anti C3'-endo conformation. The bulge is involved in a base-triple (C.g)*a interaction with the end base-pair (C9.g10) in the minor groove of a symmetry-related molecule. The 2' hydroxyl group of g15 is hydrogen bonded to O2P and O5' of g17, skipping the bulged adenine a16 and stabilizing the sugar-phosphate backbone of the hybrid. The hydrogen bonding and the backbone conformation at the bulged adenine site is very similar to that found in the crystal structure of a protein-RNA complex. | lld:pubmed |
| pubmed-article:10860725 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10860725 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10860725 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10860725 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10860725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10860725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10860725 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10860725 | pubmed:month | May | lld:pubmed |
| pubmed-article:10860725 | pubmed:issn | 0022-2836 | lld:pubmed |
| pubmed-article:10860725 | pubmed:author | pubmed-author:Sundaralingam... | lld:pubmed |
| pubmed-article:10860725 | pubmed:author | pubmed-author:Sudarsanakuma... | lld:pubmed |
| pubmed-article:10860725 | pubmed:author | pubmed-author:XiongYY | lld:pubmed |
| pubmed-article:10860725 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10860725 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:10860725 | pubmed:volume | 299 | lld:pubmed |
| pubmed-article:10860725 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10860725 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10860725 | pubmed:pagination | 103-12 | lld:pubmed |
| pubmed-article:10860725 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:10860725 | pubmed:meshHeading | pubmed-meshheading:10860725... | lld:pubmed |
| pubmed-article:10860725 | pubmed:meshHeading | pubmed-meshheading:10860725... | lld:pubmed |
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| pubmed-article:10860725 | pubmed:meshHeading | pubmed-meshheading:10860725... | lld:pubmed |
| pubmed-article:10860725 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10860725 | pubmed:articleTitle | Crystal structure of an adenine bulge in the RNA chain of a DNA.RNA hybrid, d(CTCCTCTTC).r(gaagagagag). | lld:pubmed |
| pubmed-article:10860725 | pubmed:affiliation | Department of Chemistry, Biochemistry, Ohio State University, Columbus 43210, USA. | lld:pubmed |
| pubmed-article:10860725 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10860725 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10860725 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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