| pubmed-article:10853671 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10853671 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:10853671 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10853671 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:10853671 | lifeskim:mentions | umls-concept:C0030957 | lld:lifeskim |
| pubmed-article:10853671 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:10853671 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10853671 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:10853671 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:10853671 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:10853671 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:10853671 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:10853671 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10853671 | pubmed:dateCreated | 2000-11-15 | lld:pubmed |
| pubmed-article:10853671 | pubmed:abstractText | Replication of human immunodeficiency virus type 1 (HIV-1) requires specific interactions of Tat protein with the transactivation responsive region (TAR) RNA, a 59-base stem-loop structure located at the 5'-end of all HIV mRNAs. A number of cyclic peptides are known to possess antibiotic activity and increased biological stability. Here we report the design, synthesis, and biological activity of a cyclic peptide (2), which inhibits transcriptional activation by Tat protein in human cells with an IC50 of approximately 40 nM. Cyclic peptides that can target specific RNA structures provide a new class of small molecules that can be used to control cellular processes involving RNA-protein interactions in vivo. | lld:pubmed |
| pubmed-article:10853671 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10853671 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10853671 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10853671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10853671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10853671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10853671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10853671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10853671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10853671 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10853671 | pubmed:month | May | lld:pubmed |
| pubmed-article:10853671 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:10853671 | pubmed:author | pubmed-author:HuqII | lld:pubmed |
| pubmed-article:10853671 | pubmed:author | pubmed-author:RanaT MTM | lld:pubmed |
| pubmed-article:10853671 | pubmed:author | pubmed-author:TamilarasuNN | lld:pubmed |
| pubmed-article:10853671 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10853671 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10853671 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:10853671 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10853671 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10853671 | pubmed:pagination | 971-4 | lld:pubmed |
| pubmed-article:10853671 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:10853671 | pubmed:meshHeading | pubmed-meshheading:10853671... | lld:pubmed |
| pubmed-article:10853671 | pubmed:meshHeading | pubmed-meshheading:10853671... | lld:pubmed |
| pubmed-article:10853671 | pubmed:meshHeading | pubmed-meshheading:10853671... | lld:pubmed |
| pubmed-article:10853671 | pubmed:meshHeading | pubmed-meshheading:10853671... | lld:pubmed |
| pubmed-article:10853671 | pubmed:meshHeading | pubmed-meshheading:10853671... | lld:pubmed |
| pubmed-article:10853671 | pubmed:meshHeading | pubmed-meshheading:10853671... | lld:pubmed |
| pubmed-article:10853671 | pubmed:meshHeading | pubmed-meshheading:10853671... | lld:pubmed |
| pubmed-article:10853671 | pubmed:meshHeading | pubmed-meshheading:10853671... | lld:pubmed |
| pubmed-article:10853671 | pubmed:meshHeading | pubmed-meshheading:10853671... | lld:pubmed |
| pubmed-article:10853671 | pubmed:meshHeading | pubmed-meshheading:10853671... | lld:pubmed |
| pubmed-article:10853671 | pubmed:meshHeading | pubmed-meshheading:10853671... | lld:pubmed |
| pubmed-article:10853671 | pubmed:meshHeading | pubmed-meshheading:10853671... | lld:pubmed |
| pubmed-article:10853671 | pubmed:meshHeading | pubmed-meshheading:10853671... | lld:pubmed |
| pubmed-article:10853671 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10853671 | pubmed:articleTitle | Design, synthesis, and biological activity of a cyclic peptide: an inhibitor of HIV-1 tat-TAR interactions in human cells. | lld:pubmed |
| pubmed-article:10853671 | pubmed:affiliation | Department of Pharmacology, Robert Wood Johnson Medical School, and Molecular Biosciences Graduate Program at Rutgers State University, Piscataway, NJ 08854, USA. | lld:pubmed |
| pubmed-article:10853671 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:10853671 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10853671 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10853671 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10853671 | lld:pubmed |
