| pubmed-article:10846063 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10846063 | lifeskim:mentions | umls-concept:C0037224 | lld:lifeskim |
| pubmed-article:10846063 | lifeskim:mentions | umls-concept:C0024400 | lld:lifeskim |
| pubmed-article:10846063 | lifeskim:mentions | umls-concept:C0021699 | lld:lifeskim |
| pubmed-article:10846063 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:10846063 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:10846063 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:10846063 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:10846063 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:10846063 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:10846063 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:10846063 | pubmed:dateCreated | 2000-8-10 | lld:pubmed |
| pubmed-article:10846063 | pubmed:abstractText | The human and simian immunodeficiency virus (HIV-1 and SIVmac) transmembrane proteins contain unusually long intracytoplasmic domains (ICD-TM). These domains are suggested to play a role in envelope fusogenicity, interaction with the viral matrix protein during assembly, viral infectivity, binding of intracellular calmodulin, disruption of membranes, and induction of apoptosis. Here we describe a novel mutant virus, SIVmac-M4, containing multiple mutations in the coding region for the ICD-TM of pathogenic molecular clone SIVmac239. Parental SIVmac239-Nef+ produces high-level persistent viremia and simian AIDS in both juvenile and newborn rhesus macaques. The ICD-TM region of SIVmac-M4 contains three stop codons, a +1 frameshift, and mutation of three highly conserved, charged residues in the conserved C-terminal alpha-helix referred to as lentivirus lytic peptide 1 (LLP-1). Overlapping reading frames for tat, rev, and nef are not affected by these changes. In this study, four juvenile macaques received SIVmac-M4 by intravenous injection. Plasma viremia, as measured by branched-DNA (bDNA) assay, reached a peak at 2 weeks postinoculation but dropped to below detectable levels by 12 weeks. At over 1.5 years postinoculation, all four juvenile macaques remain healthy and asymptomatic. In a subsequent experiment, four neonatal rhesus macaques were given SIVmac-M4 intravenously. These animals exhibited high levels of viremia in the acute phase (2 weeks postinoculation) but are showing a relatively low viral load in the chronic phase of infection, with no clinical signs of disease for 1 year. These findings demonstrated that the intracytoplasmic domain of the transmembrane Env (Env-TM) is a locus for attenuation in rhesus macaques. | lld:pubmed |
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| pubmed-article:10846063 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10846063 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10846063 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10846063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10846063 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10846063 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10846063 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:10846063 | pubmed:author | pubmed-author:GardnerM BMB | lld:pubmed |
| pubmed-article:10846063 | pubmed:author | pubmed-author:WeberC JCJ | lld:pubmed |
| pubmed-article:10846063 | pubmed:author | pubmed-author:LuciwP APA | lld:pubmed |
| pubmed-article:10846063 | pubmed:author | pubmed-author:ShawK EKE | lld:pubmed |
| pubmed-article:10846063 | pubmed:author | pubmed-author:ShacklettB... | lld:pubmed |
| pubmed-article:10846063 | pubmed:author | pubmed-author:SonigoPP | lld:pubmed |
| pubmed-article:10846063 | pubmed:author | pubmed-author:KeddieE MEM | lld:pubmed |
| pubmed-article:10846063 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10846063 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:10846063 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10846063 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10846063 | pubmed:pagination | 5836-44 | lld:pubmed |
| pubmed-article:10846063 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10846063 | pubmed:meshHeading | pubmed-meshheading:10846063... | lld:pubmed |
| pubmed-article:10846063 | pubmed:meshHeading | pubmed-meshheading:10846063... | lld:pubmed |
| pubmed-article:10846063 | pubmed:meshHeading | pubmed-meshheading:10846063... | lld:pubmed |
| pubmed-article:10846063 | pubmed:meshHeading | pubmed-meshheading:10846063... | lld:pubmed |
