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pubmed-article:10799971pubmed:abstractTextLinkage analyses of simulated quantitative trait data were performed using the Haseman-Elston (H-E) sib pair regression test to investigate the effects of inaccurate allele frequency estimates on the type I error rates of this test. Computer simulations generating a quantitative trait in nuclear families were performed using GASP [1]. Assuming no linkage, several data sets were simulated; they differed in marker allele numbers and frequencies, number of sib pairs and number of sibships. Each set of simulated data was analyzed using (1) all parental marker data, (2) half of the parental marker data, and (3) no parental marker data, using both correct and incorrect allele frequencies in the latter 2 cases. The H-E sib pair linkage method was found to be robust to misspecification of marker allele frequencies regardless of the number of alleles.lld:pubmed
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pubmed-article:10799971pubmed:authorpubmed-author:WilsonA FAFlld:pubmed
pubmed-article:10799971pubmed:authorpubmed-author:ElstonR CRClld:pubmed
pubmed-article:10799971pubmed:authorpubmed-author:KeatsB JBJlld:pubmed
pubmed-article:10799971pubmed:authorpubmed-author:Bailey-Wilson...lld:pubmed
pubmed-article:10799971pubmed:authorpubmed-author:WeissbeckerKKlld:pubmed
pubmed-article:10799971pubmed:authorpubmed-author:MandalD MDMlld:pubmed
pubmed-article:10799971pubmed:copyrightInfoCopyright 1999 S. Karger AG, Basellld:pubmed
pubmed-article:10799971pubmed:issnTypePrintlld:pubmed
pubmed-article:10799971pubmed:volume50lld:pubmed
pubmed-article:10799971pubmed:ownerNLMlld:pubmed
pubmed-article:10799971pubmed:authorsCompleteYlld:pubmed
pubmed-article:10799971pubmed:pagination126-32lld:pubmed
pubmed-article:10799971pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:10799971pubmed:articleTitleEffects of misspecification of allele frequencies on the type I error rate of model-free linkage analysis.lld:pubmed
pubmed-article:10799971pubmed:affiliationDepartment of Medicine, Section of Genetics and Geriatrics, Louisiana State University Medical Center, New Orleans, LA, USA.lld:pubmed
pubmed-article:10799971pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10799971pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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