| pubmed-article:10792391 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10792391 | lifeskim:mentions | umls-concept:C1705004 | lld:lifeskim |
| pubmed-article:10792391 | lifeskim:mentions | umls-concept:C0022742 | lld:lifeskim |
| pubmed-article:10792391 | lifeskim:mentions | umls-concept:C0442108 | lld:lifeskim |
| pubmed-article:10792391 | lifeskim:mentions | umls-concept:C0971858 | lld:lifeskim |
| pubmed-article:10792391 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10792391 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10792391 | lifeskim:mentions | umls-concept:C1517499 | lld:lifeskim |
| pubmed-article:10792391 | lifeskim:mentions | umls-concept:C0687080 | lld:lifeskim |
| pubmed-article:10792391 | lifeskim:mentions | umls-concept:C0441989 | lld:lifeskim |
| pubmed-article:10792391 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10792391 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10792391 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10792391 | pubmed:dateCreated | 2000-6-27 | lld:pubmed |
| pubmed-article:10792391 | pubmed:abstractText | We studied the effects of local IL-10 application, introduced by a recombinant human type 5 adenovirus vector, in the mouse knee joint during the early phase of CIA. One intra-articular injection with the IL-10-expressing virus (Ad5E1mIL-10) caused substantial over-expression of IL-10 in the mouse knee joint, using virus dosages which did not induce distracting inflammation. High expression of IL-10 was noted for a few days, being maximal at day 1. One intra-articular injection of Ad5E1mIL-10 in the knee joints of collagen type II (CII)-immunized mice, before onset of CIA was noted, reduced the incidence of collagen arthritis in that knee. Of high interest, the protective effect of local IL-10 expression by Ad5E1mIL-10 was not restricted to the knee joint alone. The arthritis incidence in the ipsilateral paw was highly suppressed. In contrast, local IL-10 over-expression was not effective when treatment was started after onset of CIA. Further analysis in the acute streptococcal cell wall-induced arthritis model revealed that local IL-10 over-expression markedly suppressed the production of tumour necrosis factor-alpha (TNF-alpha) and IL-1alpha, but had no significant effect on IL-1beta and IL-12 production in the inflamed synovium. These data indicate that local over-expression of IL-10 in the knee joint of mice regulates the expression of collagen arthritis, probably through down-regulation of TNF-alpha. | lld:pubmed |
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| pubmed-article:10792391 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10792391 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10792391 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10792391 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10792391 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10792391 | pubmed:month | May | lld:pubmed |
| pubmed-article:10792391 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:10792391 | pubmed:author | pubmed-author:RichardsC DCD | lld:pubmed |
| pubmed-article:10792391 | pubmed:author | pubmed-author:BakkerA CAC | lld:pubmed |
| pubmed-article:10792391 | pubmed:author | pubmed-author:VegaE TET | lld:pubmed |
| pubmed-article:10792391 | pubmed:author | pubmed-author:JoostenL ALA | lld:pubmed |
| pubmed-article:10792391 | pubmed:author | pubmed-author:HelsenM MMM | lld:pubmed |
| pubmed-article:10792391 | pubmed:author | pubmed-author:Van Den... | lld:pubmed |
| pubmed-article:10792391 | pubmed:author | pubmed-author:LubbertsEE | lld:pubmed |
| pubmed-article:10792391 | pubmed:author | pubmed-author:Van Den... | lld:pubmed |
| pubmed-article:10792391 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10792391 | pubmed:volume | 120 | lld:pubmed |
| pubmed-article:10792391 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10792391 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10792391 | pubmed:pagination | 375-83 | lld:pubmed |
| pubmed-article:10792391 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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