| pubmed-article:10780261 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10780261 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:10780261 | lifeskim:mentions | umls-concept:C0038454 | lld:lifeskim |
| pubmed-article:10780261 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:10780261 | lifeskim:mentions | umls-concept:C0012512 | lld:lifeskim |
| pubmed-article:10780261 | lifeskim:mentions | umls-concept:C0534769 | lld:lifeskim |
| pubmed-article:10780261 | lifeskim:mentions | umls-concept:C0815279 | lld:lifeskim |
| pubmed-article:10780261 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10780261 | pubmed:dateCreated | 2000-5-18 | lld:pubmed |
| pubmed-article:10780261 | pubmed:abstractText | Local thrombosis of the frontal cortex (Fr1 and Fr3 fields), caused by combination of the intravenous photosensitive dye Rose Bengal administration with focused high-intensity illumination of the frontal bone, was shown to provoke a pronounced deficit in step-through passive avoidance performance in rats without concomitant motor disturbances. N-Phenylacetyl-L-prolylglycine ethyl ester (GVS-111) administered intravenously at a dose of 0.5 mg/kg/day, for the first time 1 h after ischaemic lesion and then for 9 post-operative days, with the last administration 15 min before testing, attenuated the deficit. This treatment significantly diminished the volume of the infarcted area. Thus, post-ischaemic injection of GVS-111 demonstrated both cognition-restoring and neuroprotective properties. The cognition-restoring effect is probably based on an increase in neocortical and hippocampal neuronal plasticity. Neuroprotective effects of GVS-111 combine antioxidant activity with the ability to attenuate glutamate-provoked neurotoxicity and block voltage-gated ionic channels, i.e. the compound mitigates the main metabolic shifts involved in pathogenesis of brain ischaemia. | lld:pubmed |
| pubmed-article:10780261 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10780261 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10780261 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10780261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10780261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10780261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10780261 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10780261 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10780261 | pubmed:issn | 0955-8810 | lld:pubmed |
| pubmed-article:10780261 | pubmed:author | pubmed-author:OstrovskayaR... | lld:pubmed |
| pubmed-article:10780261 | pubmed:author | pubmed-author:VoroninaT ATA | lld:pubmed |
| pubmed-article:10780261 | pubmed:author | pubmed-author:SeredeninS... | lld:pubmed |
| pubmed-article:10780261 | pubmed:author | pubmed-author:RomanovaG AGA | lld:pubmed |
| pubmed-article:10780261 | pubmed:author | pubmed-author:GudashevaT... | lld:pubmed |
| pubmed-article:10780261 | pubmed:author | pubmed-author:VictorovI VIV | lld:pubmed |
| pubmed-article:10780261 | pubmed:author | pubmed-author:BarskovI VIV | lld:pubmed |
| pubmed-article:10780261 | pubmed:author | pubmed-author:ShaninaE VEV | lld:pubmed |
| pubmed-article:10780261 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10780261 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:10780261 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10780261 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10780261 | pubmed:pagination | 549-53 | lld:pubmed |
| pubmed-article:10780261 | pubmed:dateRevised | 2009-7-7 | lld:pubmed |
| pubmed-article:10780261 | pubmed:meshHeading | pubmed-meshheading:10780261... | lld:pubmed |
| pubmed-article:10780261 | pubmed:meshHeading | pubmed-meshheading:10780261... | lld:pubmed |
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| pubmed-article:10780261 | pubmed:meshHeading | pubmed-meshheading:10780261... | lld:pubmed |
| pubmed-article:10780261 | pubmed:meshHeading | pubmed-meshheading:10780261... | lld:pubmed |
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| pubmed-article:10780261 | pubmed:meshHeading | pubmed-meshheading:10780261... | lld:pubmed |
| pubmed-article:10780261 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10780261 | pubmed:articleTitle | Memory restoring and neuroprotective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model. | lld:pubmed |
| pubmed-article:10780261 | pubmed:affiliation | Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. rita.o@postman.ru | lld:pubmed |
| pubmed-article:10780261 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10780261 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
