| pubmed-article:10761931 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10761931 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:10761931 | lifeskim:mentions | umls-concept:C1420610 | lld:lifeskim |
| pubmed-article:10761931 | lifeskim:mentions | umls-concept:C1423842 | lld:lifeskim |
| pubmed-article:10761931 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:10761931 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:10761931 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:10761931 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:10761931 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:10761931 | lifeskim:mentions | umls-concept:C1881379 | lld:lifeskim |
| pubmed-article:10761931 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10761931 | pubmed:dateCreated | 2000-4-27 | lld:pubmed |
| pubmed-article:10761931 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10761931 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10761931 | pubmed:abstractText | Naive T helper cells differentiate into two subsets, Th1 and Th2, each with distinct functions and cytokine profiles. Here, we report the isolation of T-bet, a Th1-specific T box transcription factor that controls the expression of the hallmark Th1 cytokine, IFNgamma. T-bet expression correlates with IFNgamma expression in Th1 and NK cells. Ectopic expression of T-bet both transactivates the IFNgamma gene and induces endogenous IFNgamma production. Remarkably, retroviral gene transduction of T-bet into polarized Th2 and Tc2 primary T cells redirects them into Th1 and Tc1 cells, respectively, as evidenced by the simultaneous induction of IFNgamma and repression of IL-4 and IL-5. Thus, T-bet initiates Th1 lineage development from naive Thp cells both by activating Th1 genetic programs and by repressing the opposing Th2 programs. | lld:pubmed |
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| pubmed-article:10761931 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10761931 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10761931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10761931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10761931 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10761931 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10761931 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:10761931 | pubmed:author | pubmed-author:FathmanC GCG | lld:pubmed |
| pubmed-article:10761931 | pubmed:author | pubmed-author:KimS TST | lld:pubmed |
| pubmed-article:10761931 | pubmed:author | pubmed-author:GlimcherL HLH | lld:pubmed |
| pubmed-article:10761931 | pubmed:author | pubmed-author:ZhangXX | lld:pubmed |
| pubmed-article:10761931 | pubmed:author | pubmed-author:SzaboS JSJ | lld:pubmed |
| pubmed-article:10761931 | pubmed:author | pubmed-author:CostaG LGL | lld:pubmed |
| pubmed-article:10761931 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10761931 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:10761931 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:10761931 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10761931 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10761931 | pubmed:pagination | 655-69 | lld:pubmed |
| pubmed-article:10761931 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10761931 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10761931 | pubmed:articleTitle | A novel transcription factor, T-bet, directs Th1 lineage commitment. | lld:pubmed |
| pubmed-article:10761931 | pubmed:affiliation | Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA. | lld:pubmed |
| pubmed-article:10761931 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10761931 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10761931 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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