Linked Life Data

10753667

Source:http://linkedlifedata.com/resource/pubmed/id/10753667

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pubmed-article:10753667pubmed:abstractTextWe have previously reported an association of 14-3-3epsilon isoform with calmodulin. Using the voltage-clamp technique, the present study investigated the potential role of 14-3-3 in modulating the Ca(2+)-activated Cl(-) channel (CaCC) endogenously expressed in Xenopus oocytes. Injection of 14-3-3epsilon antisense oligodeoxynucleotides resulted in potentiation of the ionomycin-induced Cl(-) current, while 14-3-3 peptide and calmodulin inhibitor, W13, suppressed the antisense-potentiated current. The data suggest that 14-3-3epsilon plays an inhibitory role in modulating the CaCC by interacting with the calmodulin-dependent pathway. The potential role of 14-3-3epsilon in other tissues and its therapeutic potential for cystic fibrosis are discussed.lld:pubmed
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pubmed-article:10753667pubmed:copyrightInfoCopyright 2000 Academic Press.lld:pubmed
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pubmed-article:10753667pubmed:articleTitleModulation of the Ca(2+)-activated Cl(-) channel by 14-3-3epsilon.lld:pubmed
pubmed-article:10753667pubmed:affiliationEpithelial Cell Biology Research Centre, Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.lld:pubmed
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