| pubmed-article:10720899 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10720899 | lifeskim:mentions | umls-concept:C1522424 | lld:lifeskim |
| pubmed-article:10720899 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:10720899 | lifeskim:mentions | umls-concept:C0022680 | lld:lifeskim |
| pubmed-article:10720899 | lifeskim:mentions | umls-concept:C0055819 | lld:lifeskim |
| pubmed-article:10720899 | lifeskim:mentions | umls-concept:C0137996 | lld:lifeskim |
| pubmed-article:10720899 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10720899 | lifeskim:mentions | umls-concept:C1512806 | lld:lifeskim |
| pubmed-article:10720899 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10720899 | pubmed:dateCreated | 2000-5-16 | lld:pubmed |
| pubmed-article:10720899 | pubmed:abstractText | The kidney function in a model of autosomal dominant polycystic kidney disease (PKD), the Han:SPRD rat, is dramatically improved by chronic ingestion of a solution of potassium citrate and citric acid (KCitr). This study investigated whether this treatment would also be beneficial in the pcy/pcy mouse, a model of autosomal recessive PKD. Starting at 1 month of age, male CD-1 pcy/pcy and normal CD-1 mice were provided with a solution of 55 mM K(3) citrate/67 mM citric acid or tap water to drink. The pcy/pcy mice on the KCitr solution failed to grow normally and showed elevated plasma urea levels when compared to water-drinking littermates. Growth of normal CD-1 mice was not affected by KCitr intake. The pcy/pcy mice were then provided with a more dilute solution of KCitr to drink: this resulted in greater kidney wet and dry weights and a higher kidney weight/body weight ratio, but no beneficial effects. We conclude that pcy/pcy mice cannot tolerate a high level of KCitr intake and that a lower level is of no benefit. Whether KCitr therapy would be helpful in patients with PKD is still an open question. | lld:pubmed |
| pubmed-article:10720899 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10720899 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10720899 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10720899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10720899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10720899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10720899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10720899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10720899 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10720899 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10720899 | pubmed:issn | 0028-2766 | lld:pubmed |
| pubmed-article:10720899 | pubmed:author | pubmed-author:TannerJ AJA | lld:pubmed |
| pubmed-article:10720899 | pubmed:author | pubmed-author:TannerG AGA | lld:pubmed |
| pubmed-article:10720899 | pubmed:author | pubmed-author:Vijayalakshmi... | lld:pubmed |
| pubmed-article:10720899 | pubmed:copyrightInfo | Copyright 2000 S. Karger AG, Basel | lld:pubmed |
| pubmed-article:10720899 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10720899 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:10720899 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10720899 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10720899 | pubmed:pagination | 270-3 | lld:pubmed |
| pubmed-article:10720899 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:10720899 | pubmed:meshHeading | pubmed-meshheading:10720899... | lld:pubmed |
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| pubmed-article:10720899 | pubmed:meshHeading | pubmed-meshheading:10720899... | lld:pubmed |
| pubmed-article:10720899 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10720899 | pubmed:articleTitle | Effects of potassium citrate/citric acid intake in a mouse model of polycystic kidney disease. | lld:pubmed |
| pubmed-article:10720899 | pubmed:affiliation | Department of Physiology and Biophysics, Indiana University School of Medicine, Indianapolis, IN 46202, USA. gtanner@iupui.edu | lld:pubmed |
| pubmed-article:10720899 | pubmed:publicationType | Journal Article | lld:pubmed |
