| pubmed-article:10715532 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10715532 | lifeskim:mentions | umls-concept:C0314883 | lld:lifeskim |
| pubmed-article:10715532 | lifeskim:mentions | umls-concept:C0026724 | lld:lifeskim |
| pubmed-article:10715532 | lifeskim:mentions | umls-concept:C0036043 | lld:lifeskim |
| pubmed-article:10715532 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:10715532 | lifeskim:mentions | umls-concept:C1522673 | lld:lifeskim |
| pubmed-article:10715532 | lifeskim:mentions | umls-concept:C0008357 | lld:lifeskim |
| pubmed-article:10715532 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:10715532 | pubmed:dateCreated | 2000-7-11 | lld:pubmed |
| pubmed-article:10715532 | pubmed:abstractText | Mucosal immune responses are known to play important roles in the establishment of protective immunity to microbial infections through mucosa. We examined the toxic effects of recombinant cholera toxin B subunit (rCTB) secreted by Gram-positive bacterium Bacillus brevis as a mucosal adjuvant. Incubation of guinea-pig peritoneal macrophages with cholera toxin (CT) or aluminium hydroxide gel (Al-gel) released a significantly higher activity of lactate dehydrogenase than did commercial natural CTB (CTB) or rCTB. Intraintestinal or intramuscular administration of CT, CTB or Al-gel caused severe histopathological reactions. CT also caused infiltration of neutrophils and irregular arrangement or partial loss of the respiratory epithelium. In addition, CT and CTB elicited vascular permeability-increasing effects. rCTB elicited no toxic effects to macrophages and no vascular permeability-increasing effects. Moreover, it is noticeable that no distinct local histopathological reactions were observed in the nasal cavity, the small-intestinal loop or the muscle given rCTB. These results suggest that, from a safety standpoint, rCTB is a useful candidate as mucosal vaccine adjuvant. | lld:pubmed |
| pubmed-article:10715532 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10715532 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10715532 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10715532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10715532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10715532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10715532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10715532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10715532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10715532 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10715532 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10715532 | pubmed:issn | 0264-410X | lld:pubmed |
| pubmed-article:10715532 | pubmed:author | pubmed-author:MiuraYY | lld:pubmed |
| pubmed-article:10715532 | pubmed:author | pubmed-author:TochikuboKK | lld:pubmed |
| pubmed-article:10715532 | pubmed:author | pubmed-author:YasudaYY | lld:pubmed |
| pubmed-article:10715532 | pubmed:author | pubmed-author:TaniguchiTT | lld:pubmed |
| pubmed-article:10715532 | pubmed:author | pubmed-author:KozukaSS | lld:pubmed |
| pubmed-article:10715532 | pubmed:author | pubmed-author:GotoNN | lld:pubmed |
| pubmed-article:10715532 | pubmed:author | pubmed-author:IsakaMM | lld:pubmed |
| pubmed-article:10715532 | pubmed:author | pubmed-author:OhkumaKK | lld:pubmed |
| pubmed-article:10715532 | pubmed:author | pubmed-author:MaeyamaJJ | lld:pubmed |
| pubmed-article:10715532 | pubmed:author | pubmed-author:MatanoKK | lld:pubmed |
| pubmed-article:10715532 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10715532 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:10715532 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:10715532 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10715532 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10715532 | pubmed:pagination | 2164-71 | lld:pubmed |
| pubmed-article:10715532 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10715532 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10715532 | pubmed:articleTitle | Safety evaluation of recombinant cholera toxin B subunit produced by Bacillus brevis as a mucosal adjuvant. | lld:pubmed |
| pubmed-article:10715532 | pubmed:affiliation | Department of Safety Research on Biologics, National Institute of Infectious Diseases, Gakuen, Musashimurayama, Tokyo, Japan. ngoto@nih.go.jp | lld:pubmed |
| pubmed-article:10715532 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10715532 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10715532 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10715532 | lld:pubmed |
