| pubmed-article:10710430 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10710430 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:10710430 | lifeskim:mentions | umls-concept:C0017429 | lld:lifeskim |
| pubmed-article:10710430 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:10710430 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:10710430 | pubmed:dateCreated | 2000-5-1 | lld:pubmed |
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| pubmed-article:10710430 | pubmed:abstractText | Not I linking clones contain sequences flanking Not I recognition sites and were previously shown to be tightly associated with CpG islands and genes. To directly assess the value of Not I clones in genome research, high density grids with 50 000 Not I linking clones originating from six representative Not I linking libraries were constructed. Altogether, these libraries contained nearly 100 times the total number of Not I sites in the human genome. A total of 3437 sequences flanking Not I sites were generated. Analysis of 3265 unique sequences demonstrated that 51% of the clones displayed significant protein similarity to SWISSPROT and TREMBL database proteins based on MSPcrunch filtering with stringent parameters. Of the 3265 sequences, 1868 (57.2%) were new sequences, not present in the EMBL and EST databases (similarity < or =90%). Among these new sequences, 795 (24.3%) showed similarity to known proteins and 712 (21.8%) displayed an identity of >75% at the nucleotide level to sequences from EMBL or EST databases. The remaining 361 (11.1%) sequences were completely new, i.e. <75% identical. The work also showed tight, specific association of Not I sites with the first exon and suggest that the so-called 3' ESTs can actually be generated from 5'-ends of genes that contain Not I sites in their first exon. | lld:pubmed |
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| pubmed-article:10710430 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10710430 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10710430 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10710430 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10710430 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10710430 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:10710430 | pubmed:author | pubmed-author:ErnbergII | lld:pubmed |
| pubmed-article:10710430 | pubmed:author | pubmed-author:OOIS KSK | lld:pubmed |
| pubmed-article:10710430 | pubmed:author | pubmed-author:WinbergGG | lld:pubmed |
| pubmed-article:10710430 | pubmed:author | pubmed-author:GizatullinRR | lld:pubmed |
| pubmed-article:10710430 | pubmed:author | pubmed-author:WahlestedtCC | lld:pubmed |
| pubmed-article:10710430 | pubmed:author | pubmed-author:XieLL | lld:pubmed |
| pubmed-article:10710430 | pubmed:author | pubmed-author:ZabarovskyE... | lld:pubmed |
| pubmed-article:10710430 | pubmed:author | pubmed-author:KashubaVV | lld:pubmed |
| pubmed-article:10710430 | pubmed:author | pubmed-author:ProtopopovAA | lld:pubmed |
| pubmed-article:10710430 | pubmed:author | pubmed-author:SkobelevaNN | lld:pubmed |
| pubmed-article:10710430 | pubmed:author | pubmed-author:PodowskiR MRM | lld:pubmed |
| pubmed-article:10710430 | pubmed:author | pubmed-author:MuravenkoO... | lld:pubmed |
| pubmed-article:10710430 | pubmed:author | pubmed-author:ZabarovskaV... | lld:pubmed |
| pubmed-article:10710430 | pubmed:author | pubmed-author:KozyrevSS | lld:pubmed |
| pubmed-article:10710430 | pubmed:author | pubmed-author:PetrenkoLL | lld:pubmed |
| pubmed-article:10710430 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:10710430 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10710430 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:10710430 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10710430 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10710430 | pubmed:pagination | 1635-9 | lld:pubmed |
| pubmed-article:10710430 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10710430 | pubmed:year | 2000 | lld:pubmed |
