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pubmed-article:10707788pubmed:abstractTextMycosis fungoides is the most frequent T-cell lymphoma of the skin. Despite numerous attempts, no tumour antigens have yet been identified. Only in one case has an idiotype-derived peptide been found to trigger CTL of the respective patient. The identification of natural antigens requires the cultivation of large amounts of tumour cells in vitro, which has been possible in two exceptional cases. The identification of synthetic epitopes for tumour-specific CTL with random peptide libraries can overcome this limitation and is a powerful tool for application in the development of immune therapies for a wide range of patients.lld:pubmed
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pubmed-article:10707788pubmed:articleTitleA T-cell epitope determined with random peptide libraries and combinatorial peptide chemistry stimulates T cells specific for cutaneous T-cell lymphoma.lld:pubmed
pubmed-article:10707788pubmed:affiliationDepartment of Dermatology, Medical Faculty Charité, Humboldt University, Berlin, Germany.lld:pubmed
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