| pubmed-article:10700473 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10700473 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:10700473 | lifeskim:mentions | umls-concept:C0086972 | lld:lifeskim |
| pubmed-article:10700473 | lifeskim:mentions | umls-concept:C1510825 | lld:lifeskim |
| pubmed-article:10700473 | lifeskim:mentions | umls-concept:C1522240 | lld:lifeskim |
| pubmed-article:10700473 | lifeskim:mentions | umls-concept:C2347644 | lld:lifeskim |
| pubmed-article:10700473 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10700473 | pubmed:dateCreated | 2000-5-1 | lld:pubmed |
| pubmed-article:10700473 | pubmed:abstractText | Using an 'oligoclonal' model, we have previously shown that mice transgenic for a mu chain (H3) and deficient for kappa chain expression display a mature B cell repertoire largely dominated by the H3/lambda1 pair, while the four H3/lambda available combinations can be observed in the immature B cell compartment. This led us to propose the existence of a positive selection process. To test this hypothesis, we have introduced the SJL lambda locus coding for a defective lambda1 chain (lambda1(s)) that creates a dysfunctional Ig receptor complex during B cell differentiation. Our results show that the lambda1(s) defect impairs the development of mature B cells when the H3-mu transgene insert is present in the hemizygous state. This suggests that the Gly --> Val substitution present in the C(lambda)1(s) chain at position 155 is sufficient to abrogate the selection of the H3/lambda1 pair. Unexpectedly, when the H3-mu transgene array is present in a homozygous state in lambda1(s) mice but not in 'wild-type' lambda1 mice (lambda1(+)), a significant number of mature B cells expressing all H3/lambda combinations can be developed. These results indicate that the overriding H3/lambda1 dominance observed in lambda1(+) mice is due to a positive selection process and not to a negative selection of other H3/lambda combinations. They also show that the export of B cells to the periphery can be controlled by the expression of the mu chain. | lld:pubmed |
| pubmed-article:10700473 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10700473 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10700473 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10700473 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10700473 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10700473 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10700473 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10700473 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10700473 | pubmed:issn | 0953-8178 | lld:pubmed |
| pubmed-article:10700473 | pubmed:author | pubmed-author:CazenaveP APA | lld:pubmed |
| pubmed-article:10700473 | pubmed:author | pubmed-author:SanchezPP | lld:pubmed |
| pubmed-article:10700473 | pubmed:author | pubmed-author:DrapierA MAM | lld:pubmed |
| pubmed-article:10700473 | pubmed:author | pubmed-author:Hachemi-Rache... | lld:pubmed |
| pubmed-article:10700473 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10700473 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:10700473 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10700473 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10700473 | pubmed:pagination | 385-95 | lld:pubmed |
| pubmed-article:10700473 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10700473 | pubmed:meshHeading | pubmed-meshheading:10700473... | lld:pubmed |
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| pubmed-article:10700473 | pubmed:meshHeading | pubmed-meshheading:10700473... | lld:pubmed |
| pubmed-article:10700473 | pubmed:meshHeading | pubmed-meshheading:10700473... | lld:pubmed |
| pubmed-article:10700473 | pubmed:meshHeading | pubmed-meshheading:10700473... | lld:pubmed |
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| pubmed-article:10700473 | pubmed:meshHeading | pubmed-meshheading:10700473... | lld:pubmed |
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| pubmed-article:10700473 | pubmed:meshHeading | pubmed-meshheading:10700473... | lld:pubmed |
| pubmed-article:10700473 | pubmed:meshHeading | pubmed-meshheading:10700473... | lld:pubmed |
| pubmed-article:10700473 | pubmed:meshHeading | pubmed-meshheading:10700473... | lld:pubmed |
| pubmed-article:10700473 | pubmed:meshHeading | pubmed-meshheading:10700473... | lld:pubmed |
| pubmed-article:10700473 | pubmed:meshHeading | pubmed-meshheading:10700473... | lld:pubmed |
| pubmed-article:10700473 | pubmed:meshHeading | pubmed-meshheading:10700473... | lld:pubmed |
| pubmed-article:10700473 | pubmed:meshHeading | pubmed-meshheading:10700473... | lld:pubmed |
| pubmed-article:10700473 | pubmed:meshHeading | pubmed-meshheading:10700473... | lld:pubmed |
| pubmed-article:10700473 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10700473 | pubmed:articleTitle | Affiliation to mature B cell repertoire and positive selection can be separated in two distinct processes. | lld:pubmed |
| pubmed-article:10700473 | pubmed:affiliation | Immunochimie Analytique, Institut Pasteur and Immunobiologie, Université Denis Diderot, 75251 Paris, France. | lld:pubmed |
| pubmed-article:10700473 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10700473 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10700473 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16071 | entrezgene:pubmed | pubmed-article:10700473 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10700473 | lld:pubmed |
