| pubmed-article:10699174 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10699174 | lifeskim:mentions | umls-concept:C0034865 | lld:lifeskim |
| pubmed-article:10699174 | lifeskim:mentions | umls-concept:C0035648 | lld:lifeskim |
| pubmed-article:10699174 | lifeskim:mentions | umls-concept:C0008664 | lld:lifeskim |
| pubmed-article:10699174 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:10699174 | lifeskim:mentions | umls-concept:C1155790 | lld:lifeskim |
| pubmed-article:10699174 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10699174 | pubmed:dateCreated | 2000-4-14 | lld:pubmed |
| pubmed-article:10699174 | pubmed:abstractText | Altered recombination patterns along non-disjoined chromosomes is the first molecular correlate identified for non-disjunction in humans. To understand better the factors related to this correlate, we have asked to what extent is recombination altered in an egg with a disomic chromosome: are patterns limited to the non-disjoined chromosome or do they extend to the entire cell? More specifically, we asked whether there is reduced recombination in the total genome of an egg with a non-disjoined chromosome 21 and no detectable recombination. We chose this subclass of non-disjoined chromosomes to enrich potentially for extremes in recombination. We found a statistically significant cell-wide reduction in the mean recombination rate in these eggs with non-disjoined chromosomes 21; no specific chromosomes were driving this effect. Most importantly, we found that this reduction was consistent with normal variation in recombination observed among eggs. Thus, given that recombination is a multifactorial trait, these data suggest that when the number of genome-wide recombination events is less than some threshold, specific chromosomes may be at an increased risk for non-disjunction. Further studies are required to confirm these results, to determine the importance of genetic and environmental factors that regulate recombination and to determine their impact on non-disjunction. | lld:pubmed |
| pubmed-article:10699174 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10699174 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10699174 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10699174 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10699174 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10699174 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10699174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10699174 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10699174 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10699174 | pubmed:issn | 0964-6906 | lld:pubmed |
| pubmed-article:10699174 | pubmed:author | pubmed-author:BrownA SAS | lld:pubmed |
| pubmed-article:10699174 | pubmed:author | pubmed-author:FeingoldEE | lld:pubmed |
| pubmed-article:10699174 | pubmed:author | pubmed-author:ShermanS LSL | lld:pubmed |
| pubmed-article:10699174 | pubmed:author | pubmed-author:BromanK WKW | lld:pubmed |
| pubmed-article:10699174 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10699174 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10699174 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:10699174 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10699174 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10699174 | pubmed:pagination | 515-23 | lld:pubmed |
| pubmed-article:10699174 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10699174 | pubmed:meshHeading | pubmed-meshheading:10699174... | lld:pubmed |
| pubmed-article:10699174 | pubmed:meshHeading | pubmed-meshheading:10699174... | lld:pubmed |
| pubmed-article:10699174 | pubmed:meshHeading | pubmed-meshheading:10699174... | lld:pubmed |
| pubmed-article:10699174 | pubmed:meshHeading | pubmed-meshheading:10699174... | lld:pubmed |
| pubmed-article:10699174 | pubmed:meshHeading | pubmed-meshheading:10699174... | lld:pubmed |
| pubmed-article:10699174 | pubmed:meshHeading | pubmed-meshheading:10699174... | lld:pubmed |
| pubmed-article:10699174 | pubmed:meshHeading | pubmed-meshheading:10699174... | lld:pubmed |
| pubmed-article:10699174 | pubmed:meshHeading | pubmed-meshheading:10699174... | lld:pubmed |
| pubmed-article:10699174 | pubmed:meshHeading | pubmed-meshheading:10699174... | lld:pubmed |
| pubmed-article:10699174 | pubmed:meshHeading | pubmed-meshheading:10699174... | lld:pubmed |
| pubmed-article:10699174 | pubmed:meshHeading | pubmed-meshheading:10699174... | lld:pubmed |
| pubmed-article:10699174 | pubmed:meshHeading | pubmed-meshheading:10699174... | lld:pubmed |
| pubmed-article:10699174 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10699174 | pubmed:articleTitle | Genome-wide variation in recombination in female meiosis: a risk factor for non-disjunction of chromosome 21. | lld:pubmed |
| pubmed-article:10699174 | pubmed:affiliation | Department of Genetics, Emory University School of Medicine, 1462 Clifton Road North-East, Atlanta, GA 30322, USA, asavage@genetics.emory.edu | lld:pubmed |
| pubmed-article:10699174 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10699174 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10699174 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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