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pubmed-article:10688052pubmed:abstractTextIn order to localize cortical areas mediating pain we now report subdural cortical potentials evoked by auditory stimulation (auditory-evoked potentials - AEPs) and by cutaneous stimulation with a laser (laser-evoked potentials - LEPs). Stimulation with the laser evokes a pure pain sensation by selective activation of nociceptors. LEPs were maximal over the inferior aspect of the central sulcus and had the same polarity on either side of the sylvian fissure. AEPs were maximal posterior to the LEP maximum and had opposite polarity on opposite sides of the sylvian fissure, consistent with the location of a known generator in the temporal operculum. Auditory P3 (event-related) potentials were maximal over the temporal base. These findings demonstrate that the LEP generator is not in secondary somatosensory cortex on the parietal operculum and is different from the P3 generator.lld:pubmed
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pubmed-article:10688052pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:10688052pubmed:articleTitleDifferent generators in human temporal-parasylvian cortex account for subdural laser-evoked potentials, auditory-evoked potentials, and event-related potentials.lld:pubmed
pubmed-article:10688052pubmed:affiliationDepartment of Neurosurgery, Johns Hopkins Hospital, Baltimore, MD 21287-7713, USA. fal@pallidum.med.jhu.edulld:pubmed
pubmed-article:10688052pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10688052pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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