| pubmed-article:10678989 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10678989 | lifeskim:mentions | umls-concept:C0156543 | lld:lifeskim |
| pubmed-article:10678989 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10678989 | lifeskim:mentions | umls-concept:C0006814 | lld:lifeskim |
| pubmed-article:10678989 | lifeskim:mentions | umls-concept:C1123019 | lld:lifeskim |
| pubmed-article:10678989 | lifeskim:mentions | umls-concept:C0015965 | lld:lifeskim |
| pubmed-article:10678989 | lifeskim:mentions | umls-concept:C2350206 | lld:lifeskim |
| pubmed-article:10678989 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10678989 | pubmed:dateCreated | 2000-3-16 | lld:pubmed |
| pubmed-article:10678989 | pubmed:abstractText | The role of the surface (S)-layer proteins of Campylobacter fetus subsp. fetus has been investigated using an ovine model of abortion. Wild-type strain 23D induced abortion in up to 90% of pregnant ewes challenged subcutaneously. Isolates recovered from both dams and fetuses expressed S-layer proteins with variable molecular masses. The spontaneous S-layer-negative variant, strain 23B, neither colonized nor caused abortions in pregnant ewes. A series of isogenic sapA and recA mutants, derived from 23D, also were investigated in this model. A mutant (501 [sapA recA(+)]) caused abortion in one of five challenged animals and was recovered from the placenta of a second animal. Another mutant (502 [sapA recA]) with no S-layer protein expression caused no colonization or abortions in challenged animals but caused abortion when administered intraplacentally. Mutants 600(2) and 600(4), both recA, had fixed expression of 97- and 127-kDa S-layer proteins, respectively. Two of the six animals challenged with mutant 600(4) were colonized, but there were no abortions. As expected, all five strains recovered expressed a 127-kDa S-layer protein. In contrast, mutant 600(2) was recovered from the placentas of all five challenged animals and caused abortion in two. Unexpectedly, one of the 16 isolates expressed a 127-kDa rather than a 97-kDa S-layer protein. Thus, these studies indicate that S-layer proteins appear essential for colonization and/or translocation to the placenta but are not required to mediate fetal injury and that S-layer variation may occur in a recA strain. | lld:pubmed |
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| pubmed-article:10678989 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10678989 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10678989 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10678989 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10678989 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10678989 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:10678989 | pubmed:author | pubmed-author:NewellD GDG | lld:pubmed |
| pubmed-article:10678989 | pubmed:author | pubmed-author:BlaserM JMJ | lld:pubmed |
| pubmed-article:10678989 | pubmed:author | pubmed-author:DworkinJJ | lld:pubmed |
| pubmed-article:10678989 | pubmed:author | pubmed-author:Grogono-Thoma... | lld:pubmed |
| pubmed-article:10678989 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10678989 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:10678989 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10678989 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10678989 | pubmed:pagination | 1687-91 | lld:pubmed |
| pubmed-article:10678989 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10678989 | pubmed:meshHeading | pubmed-meshheading:10678989... | lld:pubmed |
| pubmed-article:10678989 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10678989 | pubmed:articleTitle | Roles of the surface layer proteins of Campylobacter fetus subsp. fetus in ovine abortion. | lld:pubmed |
| pubmed-article:10678989 | pubmed:affiliation | Department of Farm Animal, Royal Veterinary College, Hertfordshire, United Kingdom. | lld:pubmed |
| pubmed-article:10678989 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10678989 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10678989 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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