| pubmed-article:10668567 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10668567 | lifeskim:mentions | umls-concept:C0175677 | lld:lifeskim |
| pubmed-article:10668567 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:10668567 | lifeskim:mentions | umls-concept:C0007776 | lld:lifeskim |
| pubmed-article:10668567 | lifeskim:mentions | umls-concept:C0022655 | lld:lifeskim |
| pubmed-article:10668567 | lifeskim:mentions | umls-concept:C0001613 | lld:lifeskim |
| pubmed-article:10668567 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:10668567 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:10668567 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10668567 | pubmed:dateCreated | 2000-3-21 | lld:pubmed |
| pubmed-article:10668567 | pubmed:abstractText | Calcium influx and elevation of intracellular free calcium ([Ca2+]i), with subsequent activation of degradative enzymes, is hypothesized to cause cell injury and death after traumatic brain injury. We examined the effects of mild-to-severe stretch-induced traumatic injury on [Ca2+]i dynamics in cortical neurons cultured on silastic membranes. [Ca2+]i was rapidly elevated after injury, however, the increase was transient with neuronal [Ca2+]i returning to basal levels by 3 h after injury, except in the most severely injured cells. Despite a return of [Ca2+]i to basal levels, there were persistent alterations in calcium-mediated signal transduction through 24 h after injury. [Ca2+]i elevation in response to glutamate or NMDA was enhanced after injury. We also found novel alterations in intracellular calcium store-mediated signaling. Neuronal calcium stores failed to respond to a stimulus 15 min after injury and exhibited potentiated responses to stimuli at 3 and 24 h post-injury. Thus, changes in calcium-mediated cellular signaling may contribute to the pathology that is observed after traumatic brain injury. | lld:pubmed |
| pubmed-article:10668567 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10668567 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10668567 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10668567 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10668567 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10668567 | pubmed:issn | 0143-4160 | lld:pubmed |
| pubmed-article:10668567 | pubmed:author | pubmed-author:EllisE FEF | lld:pubmed |
| pubmed-article:10668567 | pubmed:author | pubmed-author:WeberJ TJT | lld:pubmed |
| pubmed-article:10668567 | pubmed:author | pubmed-author:MooreS FSF | lld:pubmed |
| pubmed-article:10668567 | pubmed:author | pubmed-author:WilloughbyK... | lld:pubmed |
| pubmed-article:10668567 | pubmed:author | pubmed-author:RzigalinskiB... | lld:pubmed |
| pubmed-article:10668567 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10668567 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:10668567 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10668567 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10668567 | pubmed:pagination | 289-99 | lld:pubmed |
| pubmed-article:10668567 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10668567 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10668567 | pubmed:articleTitle | Alterations in calcium-mediated signal transduction after traumatic injury of cortical neurons. | lld:pubmed |
| pubmed-article:10668567 | pubmed:affiliation | Department of Pharmacology and Toxicology, Medical College of Virginia of Virginia Commonwealth University, Richmond, USA. | lld:pubmed |
| pubmed-article:10668567 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10668567 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10668567 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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