| pubmed-article:10666080 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10666080 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10666080 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:10666080 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:10666080 | lifeskim:mentions | umls-concept:C0027481 | lld:lifeskim |
| pubmed-article:10666080 | lifeskim:mentions | umls-concept:C0059285 | lld:lifeskim |
| pubmed-article:10666080 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:10666080 | lifeskim:mentions | umls-concept:C0635791 | lld:lifeskim |
| pubmed-article:10666080 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10666080 | pubmed:dateCreated | 2000-3-2 | lld:pubmed |
| pubmed-article:10666080 | pubmed:abstractText | The role of endothelin (ET) receptors was tested in volume-stimulated atrial natriuretic factor (ANF) secretion in conscious rats. Mean ANF responses to slow infusions (3 x 3.3 ml/8 min) were dose dependently reduced (P < 0.05) by bosentan (nonselective ET-receptor antagonist) from 64.1 +/- 18.1 (SE) pg/ml (control) to 52.6 +/- 16.1 (0.033 mg bosentan/rat), 16.1 +/- 7.6 (0. 33 mg/rat), and 11.6 +/- 6.5 pg/ml (3.3 mg/rat). The ET-A-receptor antagonist BQ-123 (1 mg/rat) had no effect relative to DMSO controls, whereas the putative ET-B antagonist IRL-1038 (0.1 mg/rat) abolished the response. In a second protocol, BQ-123 (>/=0.5 mg/rat) nonsignificantly reduced the peak ANF response (106.1 +/- 23.0 pg/ml) to 74.0 +/- 20.5 pg/ml for slow infusions (3.5 ml/8.5 min) but reduced the peak response (425.3 +/- 58.1 pg/ml) for fast infusions (6.6 ml/1 min) by 49.9% (P < 0.001) and for 340 pmoles ET-1 (328.8 +/- 69.5 pg/ml) by 83.5% (P < 0.0001). BQ-123 abolished the ET-1-induced increase in arterial pressure (21.8 +/- 5.2 mmHg at 1 min). Changes in central venous pressure were similar for DMSO and BQ-123 (slow: 0.91 and 1.14 mmHg; fast: 4.50 and 4.13 mmHg). The results suggest 1) ET-B receptors mainly mediate the ANF secretion to slow volume expansions of <1.6%/min; and 2) ET-A receptors mainly mediate the ANF response to acute volume overloads. | lld:pubmed |
| pubmed-article:10666080 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666080 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10666080 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666080 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10666080 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666080 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666080 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666080 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666080 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666080 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666080 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666080 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10666080 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10666080 | pubmed:issn | 0363-6135 | lld:pubmed |
| pubmed-article:10666080 | pubmed:author | pubmed-author:BaertschiA... | lld:pubmed |
| pubmed-article:10666080 | pubmed:author | pubmed-author:AubertJ FJF | lld:pubmed |
| pubmed-article:10666080 | pubmed:author | pubmed-author:PedrazziniTT | lld:pubmed |
| pubmed-article:10666080 | pubmed:author | pubmed-author:PenceR ARA | lld:pubmed |
| pubmed-article:10666080 | pubmed:author | pubmed-author:RoattiAA | lld:pubmed |
| pubmed-article:10666080 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10666080 | pubmed:volume | 278 | lld:pubmed |
| pubmed-article:10666080 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10666080 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10666080 | pubmed:pagination | H493-9 | lld:pubmed |
| pubmed-article:10666080 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10666080 | pubmed:meshHeading | pubmed-meshheading:10666080... | lld:pubmed |
| pubmed-article:10666080 | pubmed:meshHeading | pubmed-meshheading:10666080... | lld:pubmed |
| pubmed-article:10666080 | pubmed:meshHeading | pubmed-meshheading:10666080... | lld:pubmed |
| pubmed-article:10666080 | pubmed:meshHeading | pubmed-meshheading:10666080... | lld:pubmed |
| pubmed-article:10666080 | pubmed:meshHeading | pubmed-meshheading:10666080... | lld:pubmed |
| pubmed-article:10666080 | pubmed:meshHeading | pubmed-meshheading:10666080... | lld:pubmed |
| pubmed-article:10666080 | pubmed:meshHeading | pubmed-meshheading:10666080... | lld:pubmed |
| pubmed-article:10666080 | pubmed:meshHeading | pubmed-meshheading:10666080... | lld:pubmed |
| pubmed-article:10666080 | pubmed:meshHeading | pubmed-meshheading:10666080... | lld:pubmed |
| pubmed-article:10666080 | pubmed:meshHeading | pubmed-meshheading:10666080... | lld:pubmed |
| pubmed-article:10666080 | pubmed:meshHeading | pubmed-meshheading:10666080... | lld:pubmed |
| pubmed-article:10666080 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10666080 | pubmed:articleTitle | Role of endothelin receptor subtypes in volume-stimulated ANF secretion. | lld:pubmed |
| pubmed-article:10666080 | pubmed:affiliation | Department of Physiology, University of Geneva School of Medicine, 1211 Geneva 4, Switzerland. alex.baertschi@medecine.unige.ch | lld:pubmed |
| pubmed-article:10666080 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10666080 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10666080 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
